The diagnosis of ocular myasthenia gravis(OMG)relies primarily on clinical history,bedside tests(such as ice pack test,fatigue test,sleep test,etc.),serum antibody measurement(AChR,MuSK,and LRP-4 antibody),and electrophysiological examination(RNS,SFEMG).A reasonable combination of different ancillary tests can enhance their sensitivity and specificity for diagnosing OMG.Treatment for OMG includes symptomatic treatment and immunosuppressive(IS)therapy.Patients with ophthalmoplegia typically require glucocorticoid(GC)therapy.Those who experience relapse after discontinuing GC or are intolerant to them may necessitate alternative is therapies such as traditional immunosuppressants or even targeted biologics.Early thymectomy is also an active treatment option for patients who do not respond well to symptomatic therapy or are unwilling to undergo IS therapy or have contraindications to it,or present with refractory AChR-Ab+OMG.This article reviews the recent literature progress on the diagnosis,treatment and prognosis of OMG,aiming to enhance clinicians'understanding of OMG and encourage early diagnosis and appropriate treatment in order to achieve better outcomes.
维普
万方数据