超临界CO2萃取干姜的工艺优化Δ

Technology Optimization of Supercritical CO2 Extraction from Zingiberis rhizoma

冯青云 ¹周昌妮 ²陈书慧 ²徐如冰 ²田效志 ²贾永艳³

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作者信息

1. 河南中医学院药学院，郑州 450046; 石家庄医学高等专科学校中药系，石家庄 050000
2. 河南中医学院药学院，郑州 450046
3. 河南中医学院药学院，郑州 450046; 呼吸疾病诊疗与新药研发河南省协同创新中心，郑州 450046
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摘要

目的：优化超临界CO2萃取干姜的工艺条件。方法：采用均匀设计法，以姜酚类成分6-姜酚、8-姜酚、10-姜酚的含量和干姜油萃取率的综合评分为指标，考察萃取压力、萃取温度、萃取时间3个因素对萃取效果的影响；同时进行验证试验。结果：优化的萃取工艺为压力25 MPa、温度30℃、时间2 h；验证试验中干姜油的平均萃取率为3.2％，综合评分为1.8742（RSD＝0.65％，n＝3）；实测值与预测值的相对偏差为0.6％。结论：所得最优萃取工艺条件稳定可行，具有温度低、耗时短等优点。

Abstract

OBJECTIVE:To optimize the technology of supercritical CO2 extraction from Zingiberis rhizoma. METHODS:With the comprehensive score of the contents of 6-ginger phenol,8-ginger phenol and 10-ginger phenol and the extraction rate of the oil from Z. rhizoma as the index,uniform design method was adopted to investigate the effects of extraction pressure,extrac-tion temperature and extraction duration on the extraction result;verification tests were conducted. RESULTS:The optimal condi-tions were as follows as the extraction pressure of 25 MPa,extraction temperature of 30 ℃ and extraction duration of 2 h. In the verification tests,the average extraction rate of the oil from Z. rhizoma was 3.2%(n=3),and the comprehensive score was 1.874 2 (RSD=0.65%,n=3),with the relative deviation of 0.6% between the measured value and the predicted value. CONCLUSIONS:The optimal extraction technology is stable and feasible,with the advantages of low temperature,short duration.

关键词

干姜/超临界CO2萃取/均匀设计/姜酚类成分/提取率

Key words

Zingiberis rhizoma/Supercritical CO2 extraction/Uniform design/Ginger phenolic components/Extraction rate

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基金项目

河南省科技攻关计划项目(092102310112)

呼吸疾病诊疗与新药研发河南省协同创新中心基金(20130012)

出版年

2016

中国药房

中国医院协会,中国药房杂志社

中国药房

CSTPCD北大核心

影响因子：0.956

ISSN：1001-0408

被引量2

参考文献量14

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