中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展
Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury
贾素霞 1徐晓敏 1杨慧聪 1刘树民1
作者信息
- 1. 黑龙江中医药大学中医药研究院,哈尔滨 150040
- 折叠
摘要
心肌缺血再灌注损伤(MIRI)是心肌梗死患者进行血运重建时的严重并发症.核转录因子红系2相关因子2(Nrf2)/血红素加氧酶1(HO-1)信号通路在MIRI病理进程中具有重要意义.目前研究发现,中药对缺血再灌注引起的心肌损伤具有很好的效果.本文基于Nrf2/HO-1信号通路总结中药复方和单体干预MIRI的作用机制,发现中药复方(益心方、温阳通脉方、定心方Ⅰ号方)以及中药单体萜类(银杏内酯、黄芪甲苷、人参皂苷等)、酚类(巴西苏木素、苏木酮A、白藜芦醇等)、醌类(芦荟素、大黄素)等均可通过激活Nrf2/HO-1信号通路,抑制氧化应激、炎症反应等,从而减轻MIRI.
Abstract
Myocardial ischemia-reperfusion injury(MIRI)is a serious complication of revascularization in patients with myocardial infarction.The nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling pathway plays an important role in the pathological process of MIRI.Currently,research has found that traditional Chinese medicine has a good effect on myocardial injury caused by ischemia-reperfusion.Based on the Nrf2/HO-1 signaling pathway,this article summarizes the action mechanism of traditional Chinese medicine formulas and monomers in intervening with MIRI.It is found that traditional Chinese medicine formulas(Yixin formula,Wenyang tongmai formula,Dingxin formula Ⅰ),monomers such as terpenoids(ginkgolides,astragaloside Ⅳ,ginsenosides),phenols(brazilin,hematoxylin A,resveratrol)and quinones(aloe,emodin)can alleviate MIRI by activating the Nrf2/HO-1 signaling pathway,inhibiting oxidative stress and inflammatory reactions,etc.
关键词
中药/心肌缺血再灌注损伤/核转录因子红系2相关因子2/血红素加氧酶1/信号通路Key words
traditional Chinese medicine/myocardial ischemia-reperfusion injury/nuclear factor erythroid 2-related factor 2/heme oxygenase-1/signaling pathway引用本文复制引用
基金项目
黑龙江省中医药学会青年人才托举工程项目(2022-2024)(黑中学会[2022]85号)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据