Meta-analysis of the efficacy and safety of Saccharomyces boulardii versus Bifidobacterium triple live bacteria in the treatment of pediatric diarrhea
OBJECTIVE To compare the efficacy and safety of Saccharomyces boulardii and Bifidobacterium triple live bacteria in the treatment of pediatric diarrhea.METHODS Retrieved from PubMed,Embase,the Cochrane Library,CBM,Wanfang data,CNKI and VIP,randomized controlled trials(RCTs)about S.boulardii(S.boulardii group)versus Bifidobacterium triple liver bacteria(Bifidobacterium group)were collected.After screening the literature,extracting data and evaluating the quality,meta-analysis was performed by using RevMan 5.3 software.RESULTS A total of 9 RCTs were included,involving 898 patients.Results of meta-analysis showed there was no statistical significance in total response rate[OR=1.69,95%CI(0.93,3.09),P=0.09],duration of diarrhea[MD=-1.39,95%CI(-3.35,0.57),P=0.16],the time of abdominal pain disappearance[MD=0.09,95%CI(-0.87,1.05),P=0.86]or the incidence of adverse reactions[OR=0.65,95%CI(0.05,8.03),P=0.74].The number of stools in S.boulardii group was significantly less than Bifidobacterium group[MD=-0.91,95%CI(-1.80,-0.02),P=0.04].The results of subgroup analysis showed that the duration of diarrhea in children with antibiotic-associated diarrhea in S.boulardii group was significantly shorter than Bifidobacterium group(P＜0.05).CONCLUSIONS The efficacy and safety of S.boulardii are similar to those of Bifidobacterium in the treatment of diarrhea,but S.boulardii is better than Bifidobacterium in terms of stool number,the duration of diarrhea in children with antibiotic-associated diarrhea.
Saccharomyces boulardiiBifidobacterium triple live bacteriapediatric diarrheaefficacysafetymeta-analysis
国家科技期刊平台
NSTL
万方数据
维普
