Advances in influential factor and drug treatment studies for taxane-induced peripheral neuropathy
There are millions of patients with taxane-induced peripheral neuropathy(TIPN),and there is no effective treatment or prevention measure in clinical practice.The occurrence of TIPN may be related to the dosage form of paclitaxel drugs,genetic and molecular markers,drug dosage and chemotherapy cycle,patient factors,etc.At present,drugs for treating TIPN mainly include those that inhibit axonal degeneration(such as dosazosin,tamsulosin),prevent mitochondrial dysfunction(such as glutathione trisulfides,antioxidants α-lipoic acid),improve calcium imbalance in the internal environment(Shaoyao gancao decoction,N-type voltage-gated calcium channel inhibitor IPPQ),and inhibit neuroinflammation(such as chemokine inhibitors and selective interleukin-8 receptor inhibitors DF2726A).Further exploration of drug treatment strategies targeting different induction mechanisms is expected to become a new direction for precise clinical prevention and personalized treatment of TIPN.
taxanesperipheral neuropathyinfluential factortherapeutic drug
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