Gastric cancer(GC)is a common malignant tumor of the digestive tract.T helper cells 17(Th17)and T regulatory cells(Treg)are differentiated subsets of CD4+T cells.Th17/Treg imbalance has been shown to be closely related to the progression of GC.Traditional Chinese medicine(TCM)can not only improve the survival prognosis of GC patients,but also play a role in enhancing the efficacy and reducing the toxicity of postoperative chemotherapy for GC.This paper systematically sorted out the action rules of TCM in the intervention of GC by regulating Th17/Treg balance.The results showed that the TCM compound could regulate the balance of GC Th17/Treg by invigorating the spleen and invigorating Qi,warming Yang,removing blood stasis and detoxifying.The mechanism of regulating Th17/Treg balance in the intervention of GC is mainly to inhibit the excessive differentiation of Th17 and Treg and the overexpression of transcription factors and cytokines,reverse the excessive drift of GC Th17/Treg balance to Th17 or Treg,and thus restore the immune balance of GC Th17/Treg.
关键词
中药/胃癌/辅助性T细胞17/调节性T细胞/免疫平衡/临床疗效/作用机制
Key words
traditional Chinese medicine/gastric cancer/T helper cell 17/T regulatory cells/immune balance/clinical effect/mechanism of action
维普
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