Study on the risk factors of cefoperazone/sulbactam-induced coagulation dysfunction in adult patients:a systematic review
OBJECTIVE To systematically evaluate the risk factors for cefoperazone/sulbactam-induced coagulation dysfunction in adult patients.METHODS Retrieved from CNKI,VIP,CBM,Wanfang data,PubMed,Embase and Cochrane Library,randomized controlled trial(RCT),case-control study or cohort study about cefoperazone/sulbactam-induced coagulation dysfunction in adult patients were collected from the inception to Apr.30th,2023.After literature screening,data extraction and quality evaluation,meta-analysis was carried out by using RevMan 5.3 software.RESULTS A total of 13 studies were included,among which 11 studies were case-control studies,and 2 studies were cohort studies,involving 18 387 patients in total.Meta-analysis showed that the proportion of advanced age[OR=2.04,95%CI(1.14,3.64),P=0.02],liver insufficiency[OR=5.95,95%CI(4.21,8.40),P＜0.000 01],renal insufficiency[OR=3.51,95%CI(3.04,4.05),P＜0.001],hypoproteinemia[OR= 1.90,95%CI(1.37,2.62),P＜0.001],poor diet[OR=7.25,95%CI(5.13,10.24),P＜0.000 01],daily dose of cefoperazone/sulbactam≥9 g[OR=3.95,95%CI(2.45,6.37),P＜0.001],medication duration of cefoperazone/sulbactam≥10 d[OR=2.43,95%CI(1.81,3.28),P＜0.001],combined use of anticoagulant drugs[OR=2.84,95%CI(2.03,3.97),P＜0.001],combined with malignant tumor[OR=1.60,95%CI(1.20,2.15),P＜0.001]in patients with abnormal coagulation function were significantly higher than those with normal coagulation function.CONCLUSIONS Advanced age,liver insufficiency,renal insufficiency,complicated with malignant tumors and hypoalbuminemia,combined use of anticoagulant drugs,poor diet,daily dose≥9 g,and medication duration≥10 days are risk factors for coagulation dysfunction caused by cefoperazone/sulbactam.
万方数据
维普
