摘要
腱骨愈合是一种复杂的生物学过程,多条信号通路参与其中,如转化生长因子β信号通路、骨形态发生蛋白信号通路、Wnt信号通路、成纤维细胞生长因子信号通路、核因子κB信号通路等.本文总结了中药调控相关信号通路促进腱骨愈合的研究现状,发现多种中药单体或提取物(如黄芩素、淫羊藿苷、骨碎补总黄酮、小白菊内酯、三七总皂苷等)及中药复方(如桃红四物汤、六味地黄丸、续筋接骨液等)能够通过调节以上信号通路促进骨形成、抗炎、抗氧化等,进而有效促进腱骨愈合.
Abstract
Tendon-bone healing is a complex biological process.Multiple signaling pathways are involved in tendon-bone healing,including transforming growth factor-β signaling pathway,bone morphogenetic protein signaling pathway,Wnt signaling pathway,fibroblast growth factor signaling pathway and nuclear transcription factor-κB signaling pathway.This paper summarizes the research status of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing.It is found that a variety of traditional Chinese medicine monomers or herbal extracts(such as baicalein,icariin,total flavonoids of Drynaria fortunei,parthenolide,total saponins of Panax notoginseng,etc.)and traditional Chinese medicine compounds(such as Taohong siwu decoction,Liuwei dihuang pill,Xujin jiegu liquid,etc.)can promote bone formation,anti-inflammatory,anti-oxidation,by regulating the above signaling pathways,thereby effectively promoting tendon-bone healing.
基金项目
甘肃省自然科学基金项目(18JR3RA077)
兰州市卫生健康科技发展项目(2019-050)
兰州市人才创新创业项目(2020-RC-67)
甘肃中医药大学附属医院院内课题(gzfy-2019-18)
维普
万方数据