OBJECTIVE To study the extraction technology of Sophora flavescens-Phellodendron chinense drug pair and provide a reference for the development of new drugs for the treatment of anorectal diseases.METHODS Using the contents of total alkaloids of S.flavescens(matrine+oxymatrine),berberine hydrochloride and total flavonoid,and extract yield as evaluation indicators,analytic hierarchy process-entropy weight method was used to calculate the weight coefficient of each indicator,and was combined with Box-Behnken design-response surface method to study the extraction technology of S.flavescens-P.chinense drug pair and verify it.RESULTS The optimal extraction technology of S.flavescens-P.chinense drug pair was immersed in 12-fold amount of 58%ethanol for 30 minutes and extracted twice,each time for 120 minutes.The relative error between the verification experimental results and the predicted value was 1.88%.CONCLUSIONS The obtained extraction technology is stable and feasible and can provide reference for the application of S.flavescens-P.chinense drug pair and development of new drugs.
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