首页|苦参-黄柏药对的提取工艺研究

苦参-黄柏药对的提取工艺研究

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目的 研究苦参-黄柏药对的提取工艺，为治疗肛肠疾病的新药开发提供参考依据。方法 以苦参总碱(苦参碱+氧化苦参碱)含量、盐酸小檗碱含量、总黄酮含量及浸膏得率为评价指标，采用层次分析法-熵权法计算各指标权重系数，结合Box-Behnken设计-响应面法研究苦参-黄柏药对的最佳提取工艺并进行验证。结果 苦参-黄柏药对的最优提取工艺为以12倍量58%乙醇浸泡30 min后提取2次，每次120 min。验证实验结果与预测值的相对误差为1。88%。结论 所得提取工艺稳定、可行，可为苦参-黄柏药对的进一步应用与新药开发提供参考。
Study on extraction technology of Sophora flavescens-Phellodendron chinense drug pair
OBJECTIVE To study the extraction technology of Sophora flavescens-Phellodendron chinense drug pair and provide a reference for the development of new drugs for the treatment of anorectal diseases.METHODS Using the contents of total alkaloids of S.flavescens(matrine+oxymatrine),berberine hydrochloride and total flavonoid,and extract yield as evaluation indicators,analytic hierarchy process-entropy weight method was used to calculate the weight coefficient of each indicator,and was combined with Box-Behnken design-response surface method to study the extraction technology of S.flavescens-P.chinense drug pair and verify it.RESULTS The optimal extraction technology of S.flavescens-P.chinense drug pair was immersed in 12-fold amount of 58%ethanol for 30 minutes and extracted twice,each time for 120 minutes.The relative error between the verification experimental results and the predicted value was 1.88%.CONCLUSIONS The obtained extraction technology is stable and feasible and can provide reference for the application of S.flavescens-P.chinense drug pair and development of new drugs.

Sophora flavescensPhellodendron chinensedrug pairBox-Behnken designresponse surface methodextraction technologyanalytic hierarchy processentropy weight methodhemorrhoids

管咏梅、陶颖、邹成玉、臧振中、陈丽华、刘丽丽、陈丽梅、朱卫丰

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江西中医药大学现代中药制剂教育部重点实验室,南昌 330004

江西中医药大学附属医院科研科,南昌 330004

苦参 黄柏 药对 Box-Behnken设计 响应面法 提取工艺 层次分析法 熵权法 痔疮

国家自然科学基金全国中药特色技术传承人才培训项目江西中医药大学大学生创新创业训练计划(2023)

82360812国中医药人教函[2023]96号X202310412176

2024

10.6039/j.issn.1001-0408.2024.07.05

中国药房
中国医院协会,中国药房杂志社

中国药房

CSTPCD北大核心
影响因子：0.956
ISSN：1001-0408
年,卷(期)：2024.35(7)
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