摘要
食管癌(EC)是常见的消化系统恶性肿瘤,预后极差.微RNA(miRNA)是肿瘤发生、发展的重要调控因子,可参与肿瘤细胞增殖、侵袭、转移和凋亡等恶性生物学行为.中药具有疗效确切、作用广泛、副作用小的特点,故本文以miRNA为切入点,系统阐述中药调节miRNA干预EC的作用机制.结果发现,姜黄素、款冬花多糖、白术多糖、麦冬皂苷B等中药有效成分和豆根管食通口服液可上调miRNA-532-3p(miR-532-3p)、miR-551b-3p、miR-99a、miR-34a、miR-199a-3p、miR-377等miRNA的表达,白杨素、藤梨根提取物等中药有效成分/部位和柴胡疏肝散合旋覆代赭汤、加味橘皮竹茹汤等中药复方可下调miR-199a-3p、miR-451、miR-21等miRNA的表达,从而调控信号通路(磷脂酰肌醇3激酶/蛋白激酶B等)、下游蛋白(锌指和同源框蛋白1等)或酶类(胸腺激酶1等)的表达,抑制EC细胞的增殖、侵袭和转移,诱导其凋亡,最终达到延缓EC进展的目的.
Abstract
Esophageal cancer(EC)is a common malignant tumor of the digestive system with an extremely poor prognosis.MicroRNA(miRNA)is an important regulator in tumor occurrence and development,and can participate in malignant biological behaviors such as tumor cell proliferation,invasion,metastasis and apoptosis.Traditional Chinese medicine has the characteristics of accurate curative effects,wide range of effects,and few side effects.The review uses miRNA as the entry point to systematically elaborate on the mechanism of traditional Chinese medicine-mediated miRNA intervening in EC.The results showed that active ingredients of traditional Chinese medicine(including curcumin,Tussilago farfara polysaccharides,Atractylodes macrocephala polysaccharides and ophiopogonin B)and Dougen guanshitong oral liquid could up-regulate the expressions of miRNAs such as miRNA-532-3p(miR-532-3p),miR-551b-3p,miR-99a,miR-34a,miR-199a-3p and miR-377;and the active ingredients/parts of traditional Chinese medicine(including chrysin and Actinidia arguta extract),and Chinese herbal formulas(including Chaihu shugan san combined with Xuanfu daizhe decoction and Modified jupi zhuru decoction)could down-regulate the expressions of miRNAs such as miR-199a-3p,miR-451 and miR-21,which could regulate the expressions of signaling pathways(phosphoinositide 3-kinase/protein kinase B,etc.)or their downstream protein(zinc-finger and homeobox protein 1,etc.)or enzymes(thymidine kinase-1,etc.),inhibit the proliferation,invasion and metastasis of EC cells and induce apoptosis,thereby ultimately achieving the purpose of preventing the disease from aggravating.
基金项目
国家中医药局岐黄学者培养项目(国中医药人教函[2021]203号)
广西壮族自治区重点研发计划(桂科AB23026098)
广西中医药大学B类桂派中医药传承创新团队项目(2022B001)
国家科技期刊平台
NSTL
万方数据