骨碎补活性成分促进骨缺损后骨重建的机制及其组织工程学应用
Mechanism and application in tissue engineering of the active ingredient of Drynariae Rhizoma promoting bone defect repair
邓志军 1杨文龙 2杨智军 1赵斌 1李典 1杨凤云2
作者信息
- 1. 江西中医药大学研究生院,南昌 330004
- 2. 江西中医药大学附属医院骨科,南昌 330006
- 折叠
摘要
骨缺损的治疗难度大、周期长,一直都是骨科临床面临的重大挑战.骨碎补是我国中医骨伤科的常用药材,其活性成分(主要为黄酮类)可促进骨髓间充质干细胞成骨分化、成骨细胞增殖、成血管-成骨耦联,抑制破骨细胞活力,从而促进骨缺损区的骨质矿化和修复重建.骨碎补活性成分是骨再生治疗药物的良好替代品,将其负载于组织工程支架材料上,可极大地提高药物的生物利用度.同时,缓释微球进一步解决了支架药物的突发性释放等问题,应用其所制备的含骨碎补活性成分的复合支架具有较好的成骨活性和骨诱导性,骨修复效果确切,可满足骨移植物的多样化性能要求,临床应用前景广阔.
Abstract
Bone defect has always been a major clinical challenge because of its great difficulty and long period of treatment.Drynariae Rhizoma is a commonly used medicine in osteology and traumatology of traditional Chinese medicine,and its active ingredients(mainly flavonoids)facilitate osteoblast differentiation of bone marrow mesenchymal stem cells,osteoclast proliferation,vascular-osteogenic coupling,and inhibit osteoclast activity to promote bone mineralization,and repair and reconstruction of bone defect.As a good substitute for bone regeneration drugs,the active constituents of Drynariae Rhizoma can be loaded on scaffold materials of tissue engineering,which greatly improves the bioavailability of the drug.Meanwhile,the sustained-release microspheres also solve some problems such as sudden drug release from the scaffolds,and the composite scaffolds with active ingredient of Drynariae Rhizoma prepared by them have good ossification activity and osteoinduction,with precise bone repair effects,which meet the diverse performance requirements of bone grafts and have a promising clinical application prospect.
关键词
骨碎补/活性成分/总黄酮/骨缺损/骨组织工程Key words
Drynariae Rhizoma/active ingredient/total flavonoids/bone defect/bone tissue engineering引用本文复制引用
基金项目
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)
江西省省级科技计划(20212-BCG74004)
江西省中医药局重点研究室、临床研究基地建设项目(赣中医药科教字[2020]6号)
江西省研究生创新专项(YC2022-s876)
江西中医药大学大学生创新创业训练计划(X202310412165)
出版年
2024
国家科技期刊平台
NSTL
万方数据