摘要
莪术油是从莪术中提取的挥发油,化学成分主要以单萜(包括α-蒎烯、β-蒎烯等)、倍半萜(包括β-榄香烯、莪术醇、莪术二酮等)为主,对卵巢癌、宫颈癌、结直肠癌、肺癌、肝癌等多种恶性肿瘤具有较好的治疗作用.莪术油主要通过调控血管内皮生长因子、核因子κB、信号转导及转录激活因子3等信号通路,发挥抑制肿瘤血管生成、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、阻滞细胞周期等作用.目前,莪术油因难溶于水、稳定性差等缺点限制了其在临床上的应用,现代制剂研究则采用新技术将其制备成脂质体、微球、微乳/纳米乳等,从而改善了莪术油的溶解性和稳定性.本文归纳总结了国内外近年来莪术油化学成分、抗肿瘤作用及制剂研究进展,可为莪术油在抗肿瘤方面的应用及制剂研发提供理论依据.
Abstract
Zedoary turmeric oil,volatile oil extracted from zedoary turmeric,composed mainly of monoterpenes(including α-pinene,β-pinene,etc.)and sesquiterpenes(including β-elemene,zedoary alcohol,zedoary ketone,etc.),and has been used in clinical practice to treat various malignant tumors such as ovarian cancer,cervical carcinoma,colorectal cancer,lung cancer and liver cancer.Zedoary turmeric oil regulates vascular endothelial growth factor and nuclear factors-κB,signal transducers and activator of transcription 3 signaling pathways to play a role in inhibiting tumor angiogenesis,inhibiting tumor cell proliferation,inducing tumor cell apoptosis,and blocking cell cycle.However,due to its insolubility in water and poor stability,its clinical application is limited;the application of new formulations and technologies such as liposomes,microspheres,and nanoemulsion improves the solubility and stability of zedoary turmeric oil.This paper summarizes recent research progress on the chemical composition,anti-tumor effects,and formulations of zedoary turmeric oil,both domestically and internationally,providing a reference for further expanding the clinical application and formulation development of zedoary turmeric oil in the anti-tumor field.
基金项目
国家重点研发计划(2022YFC3501900)
江西省重点研发计划(20232BBG70016)
中国中医科学院科技创新工程项目(CI2021A04301)
国家科技期刊平台
NSTL
万方数据