Effects of 0.2%chloroprocaine combined with ropivacaine on epidural labor analgesia and EC50 of ropivacaine
OBJECTIVE To investigate the effects of 0.2%chloroprocaine combined with ropivacaine on epidural labor analgesia and median effective concentration(EC50)of ropivacaine.METHODS Totally 67 parturients who scheduled for vaginal delivery and required epidural labor analgesia were collected from our hospital from July to October 2023 and randomly divided into RL group(33 cases)and R group(34 cases).The concentration of ropivacaine was determined by modified Dixon sequential method.RL group was given 0.2%Chloroprocaine hydrochloride injection+Ropivacaine hydrochloride injection+0.4 μg/mL Sufentanil citrate injection;R group was given Ropivacaine hydrochloride injection+0.4 μg/mL Sufentanil citrate injection.EC50 of ropivacaine,analgesic effect during delivery,total dosage of analgesic drugs,analgesic satisfaction score,the incidence of adverse reactions,delivery status,and Apgar score of newborns were observed in two groups.RESULTS EC50 of ropivacaine,onset time,remedial analgesia rate,the incidence of perineal distension and breakthrough pain and total dosage of analgesic drugs of RL group were significantly lower than R group,and analgesic satisfaction score was significantly higher than R group(P＜0.05).There was no statistical significance in the incidence of adverse reactions such as numbness,weakness,and chills in the lower limbs,or the duration of labor,amount of bleeding,mode of delivery,and Apgar score of newborns between 2 groups(P＞0.05).CONCLUSIONS For epidural labor analgesia,0.2%chloroprocaine combined with ropivacaine can reduce EC50 of ropivacaine,improve analgesia effect and have good safety.
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