Research progress of active components and compounds of traditional Chinese medicine improving liver fibrosis by regulating JAK/STAT signaling pathway
Hepatic fibrosis is a pathological process of chronic liver injury.Without timely intervention and treatment,liver fibrosis may eventually lead to liver cirrhosis and cancer.Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway is closely associated with the occurrence and development of liver fibrosis.Based on this,this paper summarized and analyzed the mechanism and effects of active ingredients and compounds of traditional Chinese medicine improving liver fibrosis based on JAK/STAT signaling pathway.It is found that the active ingredients and compounds of traditional Chinese medicine that promote blood circulation and remove blood stasis(ingredients such as ethanol extract of Euonymus alatus and paclitaxel,as well as compounds such as Ershiwuwei songshi pill and Ganfukang),clear away heat and toxic material(ingredients such as betulinic acid,total flavonoids from Persicaria perfoliata,as well as compounds such as Pianzaihuang and Kehuang capsules),and sooth the liver and promote qi circulation(ingredients such as fraxetin and cucurbitacin B,as well as compounds such as Chaihu shugan powder and Xiaochaihu decoction)can all relieve liver fibrosis by inhibiting the activity of the JAK/STAT signaling pathway,reducing inflammatory reactions,and inhibiting the proliferation of hepatic stellate cells.
liver fibrosisJAK/STAT signaling pathwaytraditional Chinese medicineactive ingredientscompounds
万方数据
维普
