摘要
细胞自噬是由多分子多通路共同介导完成的,在心血管疾病中,自噬可以通过磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(mTOR)、腺苷一磷酸活化的蛋白激酶/mTOR、丝裂原活化蛋白激酶、p53、Wnt/β-连环蛋白等关键信号通路发挥作用.活血化瘀类中药单体如羟基红花黄色素A、人参皂苷Rb1、红景天苷、川芎内酯、姜黄素等,中药复方及制剂如黄芪保心汤、桃红四物汤、通心络胶囊、双参宁心胶囊、速效救心丸等均能通过上述关键信号通路调控细胞自噬,进而缓解心血管疾病的进程.
Abstract
Autophagy is mediated by multiple molecules and pathways.In cardiovascular diseases,autophagy can play a role through key signaling pathways such as phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK)/mTOR,mitogen-activated protein kinases(MAPK),p53,Wnt/β-catenin,etc.Traditional Chinese medicine(TCM)monomers for promoting blood circulation and removing blood stasis such as hydroxysafflor yellow A,ginsenoside Rb1,salidroside,ligustrin,curcumin,etc.,and TCM prescription and preparations such as Huangqi baoxin decoction,Taohong siwu decoction,Tongxinluo capsule,Shuangshen ningxin capsule,Suxiao jiuxin pills,etc.can regulate autophagy through the above-mentioned key signaling pathways,thereby alleviating the progression of cardiovascular diseases.
国家科技期刊平台
NSTL
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