Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy
Autophagy is mediated by multiple molecules and pathways.In cardiovascular diseases,autophagy can play a role through key signaling pathways such as phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK)/mTOR,mitogen-activated protein kinases(MAPK),p53,Wnt/β-catenin,etc.Traditional Chinese medicine(TCM)monomers for promoting blood circulation and removing blood stasis such as hydroxysafflor yellow A,ginsenoside Rb1,salidroside,ligustrin,curcumin,etc.,and TCM prescription and preparations such as Huangqi baoxin decoction,Taohong siwu decoction,Tongxinluo capsule,Shuangshen ningxin capsule,Suxiao jiuxin pills,etc.can regulate autophagy through the above-mentioned key signaling pathways,thereby alleviating the progression of cardiovascular diseases.
autophagytraditional Chinese medicinepromoting blood circulation and removing blood stasiscardiovascular disease
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