Research progress on traditional Chinese medicine improving polycystic ovary syndrome by regulating NF-κB signaling pathway
Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of childbearing age.Persistent chronic inflammation can promote the progression of PCOS,thereby causing serious impacts on women's endocrine metabolism,reproductive function,and psychological status.Nuclear factors-κB(NF-κB)signaling pathway is one of the most classic inflammatory response transduction pathways and is closely related to the pathological process of PCOS.This article summarizes the mechanism of traditional Chinese medicine intervention in PCOS based on the NF-κB signaling pathway,and finds that various monomers of traditional Chinese medicine[flavonoids(naringenin,soy isoflavone,rhamnocitrin,etc.),alkaloids(berberine,ligustrazine)and terpenoids(artesunate,cryptotanshinone),glycosides(salidroside,glycyrrhizic acid)]and traditional Chinese medicine compounds[formula for tonifying kidney(Bushen huayu formula,Bushen huatan formula,etc.),formula for eliminating damp and dissolving phlegm(Cangfu daotan decoction,Xiehe yin,Erchen decoction),formula for regulating blood circulation and removing stasis(Gexia zhuyu decoction,Huatan tongmai yin)]can alleviate inflammatory response,improve abnormal glucose and lipid metabolism,and enhance ovarian function by inhibiting NF-κB signaling pathway,thus improving PCOS.
polycystic ovary syndromeNF-κB signaling pathwaytraditional Chinese medicineinflammation
国家科技期刊平台
NSTL
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