Research advances on the pathogenesis and treatment of unexplained recurrent spontaneous abortion
Spontaneous abortion is one of the most common complications of pregnancy,and two or more spontaneous abortions in a row are defined as recurrent spontaneous abortion(RSA),of which about half of patients have unknown etiology.However,the pathogenesis of unexplained RSA(URSA)has not been elucidated,and the lack of effective treatment has made it one of the key and difficult points in the field of obstetrics and gynecology.This article conducts a literature review of recent research on URSA and finds that the pathogenesis of URSA is related to the imbalance of immune tolerance at the maternal-fetal interface,apoptosis of trophoblast cells,inhibition of angiogenesis,and activation of immune responses.Immunotherapy(including cell therapy,cytokine therapy,and immunosuppressive intervention),hormone drugs,anticoagulant regimens,and traditional Chinese medicine therapies are commonly used in clinical practice to intervene in URSA,but the safety and effectiveness of some therapies are still controversial.
国家科技期刊平台
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