摘要
胃食管反流病(GERD)是由胃内容物反流至食管引起反酸、烧心等症状的胃肠动力障碍性疾病.GERD的发生与患者焦虑、抑郁等心理障碍密切相关.脑-肠轴作为大脑与胃肠道双向联系的中介,在GERD伴焦虑抑郁症的发生发展中具有重要作用.中药复方内服疗法(平冲降逆汤、调中化湿汤等)、中医药内服外用联合疗法(连栀泄热汤联合穴位贴敷、针刺督脉背段联合疏肝利胆和胃中药等)、中西药内服联合疗法(健脾疏肝汤联合雷贝拉唑、雷贝拉唑联合建中降逆汤等)可通过调控脑肠肽、肠道菌群、炎症因子、胃肠激素等分子信号有效改善GERD症状及焦虑、抑郁状态,提升患者生活质量.
Abstract
Gastroesophageal reflux disease(GERD)is a gastrointestinal motility disorder characterized by the reflux of gastric contents into the esophagus,leading to symptoms such as acid reflux and heartburn.The incidence of GERD is closely associated with psychological disorders,including anxiety and depression.The brain-gut axis,serving as a mediator of the bidirectional connection between the brain and the gastrointestinal tract,plays a crucial role in the occurrence and development of GERD with anxiety and depression.Various therapeutic approaches,including compound Chinese medicine internal therapy(such as Pingchong jiangni decoction,Tiaozhong huashi decoction,etc.),combination therapy of internal and external Chinese medicine(such as Lianzhi xiere decoction combined with acupoint application,acupuncture at the back segment of governor vessel plus Chinese medication of soothing the liver and gallbladder,etc.),and combination therapy of intemal Chinese and westem medicine(including Jianpi shugan decoction combined with rabeprazole,rabeprazole combined with Jianzhong jiangni decoction,etc.),have been shown to regulate brain-gut peptides,intestinal flora,inflammatory factors and gastrointestinal hormones,thereby effectively alleviating GERD symptoms,anxiety and depression,and enhancing patients'quality of life.
基金项目
广西自然科学基金面上项目(2024GXNSFAA99-9154)
广西自然科学基金青年科学基金项目(2024GXNSFBA010-102)
国家自然科学基金项目(82260900)
国家自然科学基金项目(82160877)
维普
万方数据