Research progress on the mechanism of saponin compounds intervening in colorectal cancer by regulating gut microbiota
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide.Specific gut microbiota can identify high-risk populations for colorectal cancer and may slow disease progression by regulating apoptosis,producing intestinal metabolites,and enhancing chemotherapy efficacy(reducing side effects and improving chemotherapy resistance).Saponins represented by ginsenoside K are found widely in traditional medicines such as Panax ginseng and Panax notoginseng.After metabolized by gut microbiota,they play a role in preventing and treating colorectal cancer by modulating chronic inflammation,adjusting the composition of gut microbiota,generating microbial metabolites,and participating in immune regulation.
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