Chronic pain refers to pain that persists or recurs for more than 3 months and has a high comorbidity rate with emotions such as depression and anxiety.The complex pathogenesis of comorbid depressive symptoms in chronic pain poses great challenges to clinical diagnosis and treatment.This article reviews the research progress on the effect mechanism on the comorbid depressive symptoms in chronic pain by traditional Chinese medicine monomers,compound formulas,and acupuncture therapy in recent years.It is found that traditional Chinese medicine monomers(flavonoids,phenols,terpenes,coumarins,alkaloids),traditional Chinese medicine formulas(Aconitum carmichaeli decoction,Chaihu guizhi decoction,etc.),and acupuncture therapy(acupuncture at acupoints such as Baihui,Yintang,Hegu,and Taichong)can effectively improve comorbid depressive symptoms in chronic pain by regulating the levels of neurotransmitters,brain-derived neurotrophic factors and inflammatory factors,and the activity of glial cells in the central nervous system.
关键词
慢性疼痛-抑郁共病/中药单体/中药复方/神经递质/炎症/作用机制
Key words
comorbid depressive symptoms in chronic pain/traditional Chinese medicine monomer/traditional Chinese medicine compound formulas/neurotransmitters/inflammation/mechanism
维普
万方数据