Effects of TGF-β signaling pathway in the tumor microenvironment and development advance in targeted drug
Dysregulation of transforming growth factor β(TGF-β) signaling pathway is related to the occurrence and development of various pathological conditions,including tumors. In the early stage of tumorigenesis,TGF-β,as an anti-proliferation and pro-differentiation factor,plays an anticancer role. In advanced tumors,TGF-β can stimulate tumor progression and metastasis through its effect on the tumor microenvironment (such as promoting angiogenesis,fibrosis,immune suppression,and regulating cellular metabolism). A variety of TGF-β signaling pathway inhibitors have been tested in clinical trials,including monoclonal antibodies,ligand traps,small molecule inhibitors,antisense oligonucleotides,bispecial antibodies,and tumor vaccines,but no related drugs are currently approved for cancer treatment clinically. Accurately screening potential benefit patients and combining it with immune checkpoint inhibitors are its future development directions.
万方数据
维普
