Advances in therapeutic drug monitoring of invasive fungal disease
Invasive fungal disease(IFD)is a deep infectious disease with an overall increasing incidence in patients with hematologic malignancies.Triazoles,polyenes,echinocandins echinocandin antifungal drugs,5-fluorocytosine and Compound sulfamethoxazole are the main drugs used in the clinical treatment of IFD.Therapeutic drug monitoring for IFD prevention and treatment is helpful to optimize treatment outcomes and reduce adverse effects.In this paper,the effective plasma concentration ranges of the above 5 types of drugs are systematically summarized,and the correlation between the plasma concentration of antifungal drugs and the efficacy and adverse reactions is reviewed.Solid phase extraction combined with ultra-performance chromatography-tandem mass spectrometry is a promising detection method in this research field.
hematopoietic stem cell transplantationhematologic malignanciesinvasive fungal diseasetherapeutic drug monitoringanalytical methods
万方数据
维普
