Invasive fungal disease(IFD)is a deep infectious disease with an overall increasing incidence in patients with hematologic malignancies.Triazoles,polyenes,echinocandins echinocandin antifungal drugs,5-fluorocytosine and Compound sulfamethoxazole are the main drugs used in the clinical treatment of IFD.Therapeutic drug monitoring for IFD prevention and treatment is helpful to optimize treatment outcomes and reduce adverse effects.In this paper,the effective plasma concentration ranges of the above 5 types of drugs are systematically summarized,and the correlation between the plasma concentration of antifungal drugs and the efficacy and adverse reactions is reviewed.Solid phase extraction combined with ultra-performance chromatography-tandem mass spectrometry is a promising detection method in this research field.
关键词
造血干细胞移植/血液系统恶性肿瘤/侵袭性真菌病/治疗药物监测/检测方法
Key words
hematopoietic stem cell transplantation/hematologic malignancies/invasive fungal disease/therapeutic drug monitoring/analytical methods
维普
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