Meta-analysis of the incidence and risk factors of anti-tuberculosis drug-induced liver injury
OBJECTIVE To systematically evaluate the incidence of anti-tuberculosis drug-induced liver injury(ATB-DILI)and its risk factors.METHODS PubMed,Embase,the Cochrane Library,Web of Science,China Knowledge Network,VIP,Wanfang data and China Biomedical Literature Database were searched to collect cohort studies and case-control studies on the incidence and risk factors of ATB-DILI from the establishment of the database to 31 May 2024.After screening literature,extracting data and evaluating the quality of literature,meta-analysis was performed using Stata 17.0 and RevMan 5.3 software.RESULTS A total of 26 literature involving 38 971 patients were included,of which 4 106 patients suffered from ATB-DILI.Meta-analysis showed that the incidence of ATB-DILI was 12.94％[95％CI(10.82％,15.06％),P＜0.001];subgroup analysis showed that the incidence of ATB-DILI in cohort studies,Chinese studies and pediatric patients was higher(P＜0.001).Age≥60 years,abnormal body mass index,alcoholism,smoking,history of liver disease,hepatitis B surface antigen positivity,extrapulmonary tuberculosis,malnutrition,hypoproteinemia,cardiovascular disease,diabetes mellitus,systemic lupus erythematosus,no prophylactic use of hepatoprotective drugs,and high baseline alanine transaminase levels were risk factors for developing ATB-DILI(P＜0.05).Sensitivity analysis and publication bias analysis showed that the results obtained in this study were relatively robust.CONCLUSIONS The incidence of ATB-DILI in tuberculosis patients is 12.94％.Age≥60 years,abnormal body mass index,alcoholism,smoking,history of liver disease,hepatitis B surface antigen positivity,extrapulmonary tuberculosis,malnutrition,hypoproteinaemia,cardiovascular disease,diabetes mellitus,systemic lupus erythematosus,non-prophy lactic use of hepatoprotective medications,and high baseline levels of alanine transaminase are the risk factors for developing ATB-DILI.
万方数据
维普
