Evaluation of potentially inappropriate medications in elderly polypharmacy patients with diabetes mellitus according to Beers criteria combined with STOPP criteria
OBJECTIVE To provide a reference for the safe use of drugs in elderly patients with diabetes mellitus.METHODS Clinical data of elderly diabetic patients aged ≥65 years old and with ≥5 types of long-term medication who were admitted to two tertiary general hospitals in Hebei Province one day a month in 2022 were randomly selected.2023 Beers criteria and 2023 STOPP criteria were used to analyze the potentially inappropriate medication(PIM)of the patients;multivariate Logistic regression was used to analyze the influencing factors of PIM.RESULTS A total of 227 patients were included.According to the Beers criteria,157 patients(69.16％)had PIM,and the drugs with the most frequent cases of PIM were proton pump inhibitors(PPIs),sodium-glucose linked transporter-2 inhibitors and rivaroxaban.According to the STOPP criteria,142 patients(62.56％)had PIM,and the main drugs involved were non-steroidal anti-inflammatory drugs and PPIs.The results of multivariate Logistic regression analysis showed that patients with age ≥80 years old,with ≥4 other types of chronic diseases,≥ 10 types of long-term medication,≥8 days of hospitalization,medication regimen complexity index scoring ≥20 points of medication regimen,and complication with hypertension,coronary heart disease,and cerebrovascular diseases were influential factors for PIM.CONCLUSIONS The detection rate of PIM is high in elderly patients with diabetes mellitus,and the Beers criteria are more sensitive to PIM than the STOPP criteria.Clinically,we should focus on patients who are elderly,have multiple chronic diseases at the same time,have a large number of long-term medications,have a long hospital stay,have complex medication regimens,and strengthen their rational drug management.
elderly diabetes mellituspolypharmacypotentially inappropriate medicationinfluential factorsrational use of drugs
万方数据
维普
