Influence of hyperhomocysteinemia and overweight or obesity on the risk of essential hypertension in Tibetan population in Tibet Autonomous Region
Objective To analyze the interaction between hyperhomocysteinemia(HHcy)and overweight/obesity,and their effect on the risk of essential hypertension in Tibetan population in Tibet Autonomous Region.Methods Using multistage cluster random sampling,Tibetan residents in Ali,Naqu and Shannan were selected from June 2020 to October 2021 for a questionnaire survey,physical examination and homocysteine(Hcy)test.Logistic regression model was used to analyze the effect of HHcy and overweight/obesity on the risk of hypertension,and to explore the interaction between these two potential risk factors.Results The prevalence of hypertension in this area was 28.03％,45.03％of the residents were overweight/obesity,and 70.94％of the residents had HHcy.After adjusting for confounding factors,the risk of hypertension in overweight/obese people was 1.75 times that in non-overweight/obese people(95％CI:1.47-2.07,P＜0.01),the risk of hypertension in HHcy patients was 2.08 times that in people with normal Hcy level(95％CI:1.70-2.54,P＜0.01),and the risk of hypertension in people with both overweight/obesity and HHcy was 4.00 times that in people with neither condition(95％CI:3.08-5.20,P＜0.01).The results of interaction analysis showed that the relative excess risk,attributable proportion and synergy index of interaction between overweight/obesity and HHcy were 0.92(95％CI:0.22-1.62),0.23(95％CI:0.06-0.40)and 1.44(95％CI:1.04-2.00),respectively.Overweight/obesity and HHcy had a positive additive interaction on hypertension,and also a multiplicative interaction(OR=2.27,95％CI:1.95-2.65,P＜0.01).Conclusions Both HHcy and overweight/obesity are risk factors of hypertension in Tibetan population in Tibet Autonomous Region,and there are both positive additive and multiplicative interactions between these two risk factors.
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