Association of long-term exposure to atmospheric fine particulate matter and physical activity with central obesity in Chinese adults
Objective Based on the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR),this study aimed to comprehensively evaluate the association between long-term PM2.5 exposure,physical activity,waist circumference,and central obesity.Methods Individuals who participated in the China-PAR study in 2007-2008(n=104 697)or 2012-2015(n=80 235)were involved in this study.The generalized estimating equation(GEE)method was employed to assess the associations between satellite-based PM2.5 estimated at 1 X 1 km spatial resolution and waist circumference as well as central obesity with unbalanced repeat measurement design.We also evaluated the modification effect of ideal physical activity on these associations.Moreover,sensitivity analyses and subgroup analyses were also conducted.Results Each increment of 10 μg/m3 in PM2.5 concentration was associated with an increase of 1.10(95％CI:1.05-1.15)cm in waist circumference and 19％in the prevalence of central obesity(OR=1.19,95％CI:1.17-1.20).The results of categorical variables also suggest that PM2.5 exposure was significantly associated with waist circumference and the prevalence of central obesity.There were positive interactions between PM2.5 exposure and physical activity on waist circumference and central obesity.Subgroup analyses and sensitivity analyses confirmed the robustness of the results.Conclusions Long-term exposure to PM2.5 significantly increases waist circumference and the prevalence of central obesity,with a significant interaction between ideal physical activity and PM2.5 exposure.Active interventions for improving air quality and enhancing physical activity are of great importance in reducing the burden of central obesity-related diseases.
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