Survival of elderly HIV-infected/AIDS patients in Chaoyang District,Beijing
Objective To analyze the survival rate of and its influencing factors among the elderly human immunodeficiency virus(HIV)-infected/acquired immunodeficiency syndrome(AIDS)patients in Chaoyang District in Beijing.Methods Cases with HIV-infection/AIDS aged 50 years and older at diagnosis reported in the period from May 25,1999 to December 31,2020 and living in Chaoyang District,Beijing were identified and relevant information were extracted from the National HIV/AIDS Information System,including their infectious disease report cards,follow-up surveys,and status of antiretroviral therapy(ART).Historical cohort analysis was used to estimate their survival rate.Cox proportional hazards model was applied to identify the factors related with survival.Results A total of 489 cases were included.As of December 31,2020,57 cases died,and 53 cases were lost to follow-up in the cohort,with a cumulative observation time of 1 819.96 person-years and a median observation time of 2.92 person-years.The overall mortality rate was 3.13/100 person-years,and the survival rates at 1,5,10,15,and 20 years were 91.98％,85.44％,76.53％,76.53％,and 76.53％,respectively.Multivariable Cox proportional hazards model showed that,compared with the corresponding reference groups,aged ≥70 years at diagnosis,unspecified history of sexually transmitted diseases,and baseline CD4+count 0-＜200 cells/μl,unknown,or untested were associated with increased risk of death,with relative risks(RRs)(95％CI)of 4.72(2.35-9.49),2.57(1.36-4.84),and 6.23(1.84-21.04),respectively.Receiving ART was a protective factor with RR(95％CI)being 0.03(0.01-0.06)for those who started ART no more than 1 month after diagnosis,and 0.07(0.03-0.14)for those who started ART more than 1 month after diagnosis.Conclusions In order to reduce the mortality rate and prolong the survival time of elderly HIV-infected/AIDS cases,HIV health education and testing should be strengthened in this population for early detection of HIV-infected people and AIDS patients.
Human immunodeficiency virusAcquired immunodeficiency syndromeElderly peopleSurvival status
NETL
NSTL
万方数据
