Seroprevalence of pertussis antibodies in healthy populations in Yiwu City,Zhejiang Province,and Yongcheng City,Henan Province,from 2021 to 2022
Objective To investigate the level of pertussis antibody levels in healthy populations aged ≥3 years in Yiwu City,Zhejiang Province,and Yongcheng City,Henan Province,from 2021 to 2022 and evaluate the immune status against pertussis in the populations.Methods Blood samples were collected from healthy individuals aged ≥3 years in the two communities using a multi-stage stratified random sampling method.Serum pertussis toxin IgG antibodies(PT-IgG)levels were measured quantitatively by enzyme-linked immunosorbent assay(ELISA).Differences in antibody concentrations among different age groups,regions,and genders were analyzed.Results The geometric mean concentration(GMC)of antibodies in Yiwu City,Zhejiang Province,and Yongcheng City,Henan Province,were 3.79 IU/ml and 12.48 IU/ml,respectively.There was a statistically significant difference in antibody levels between the two regions(U=907 430,P＜0.01).There was no statistically significant difference in the past and recent infection rates between the two regions,with a value of 4.88％and 4.01％(x2=0.832,P=0.362).The past and recent infection rates(5.87％vs.4.18％)between adults ≥20 years old and individuals aged 3-＜20 years old in Yiwu City showed no significant difference(x2=2.506,P=0.113),while adults aged ≥20 years old in Yongcheng City,Henan Province,had higher past and recent infection rates than those aged 3-＜20(9.76％vs.1.50％)(x2=25.259,P＜0.01).The age groups with the highest past and recent infection rates in Yiwu City,Zhejiang Province,were ≥65 years old(8.33％)and 7-＜15 years old group(2.04％),respectively,while in Yongcheng City,Henan Province,both were in the ≥65 years old group(12.50％,12.50％).The estimated infection rates for pertussis in Yiwu City and Yongcheng City were 6.67％and 6.48％,respectively.Conclusions The seroprevalence of pertussis is relatively high in healthy populations in Y wu City,Zhejiang Province,and Yongcheng City,Henan Province.The antibody levels and infection rates in adults in Yongcheng City are higher than in children and adolescents,indicating the possibility of pertussis infection in vaccinated individuals Further monitoring and optimization of immunization strategies are needed.
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