Objective To understand the disease burden of hospitalized cases of human respiratory syncytial virus(HRSV)infection in children aged ≤5 years in the southern region of Zhejiang Province in 2023.Methods Collect diagnosis and treatment data of≤5-year-old hospitalized children diagnosed with HRSV through laboratory testing in two hospitals in Zhejiang Province from January 1 to May 31,2023,and analyze the disease burden of different population characteristics and risk factors for pneumonia.Results A total of 269 hospitalized cases of HRSV infection were included in this study,with pneumonia cases accounted for 232(86.25％).The median hospitalization cost for all cases was 4 326.21[interquartile range(IQR):3 281.74-5 599.92]yuan,and the median length of hospital stay was 6(IQR:4-7)d.The 0-＜1 year group had higher hospitalization costs(5 429.46 yuan vs.4 056.96 yuan)and longer hospital stays(6 d vs.5 d)compared to other age groups,with statistical significance(t=4.852,P＜0.01;t=2.618,P=0.010).Pneumonia cases had higher costs(4 212.49 yuan vs.4 052.31 yuan)and longer hospital stays(6 d vs.5 d)compared to non-pneumonia cases,with statistical significance(t=3.704,P=0.031;t=2.940,P=0.040),and mixed infections had higher costs(4 806.89 yuan vs.4 051.92 yuan)and longer hospital stays(6 d vs.5 d)compared to single infections),with statistical significance(t=3.538,P＜0.001;t=4.270,P＜0.01).Cesarean section(OR=12.72,95％CI:5.08-31.90),low birth weight(t=-3.074,P=0.002),and delayed hospital admission(t=4.880,P＜0.01)were risk factors for pneumonia in HRSV-infected hospitalized children.Conclusions Children under one-year-old with HRSV infection in the southern region of Zhejiang Province in 2023 have a heavy disease burden,and mixed infections,cesarean section,low birth weight,and delayed admission were identified as risk factors for increasing the burden of HRSV.
Human respiratory syncytial virusPneumoniaMixed infectionDisease burdenHospitalizationChildren
NETL
NSTL
万方数据
