Study on the disease burden of hospitalized children with human respiratory syncytial virus infection in southern Zhejiang Province in 2023
Objective To understand the disease burden of hospitalized cases of human respiratory syncytial virus(HRSV)infection in children aged ≤5 years in the southern region of Zhejiang Province in 2023.Methods Collect diagnosis and treatment data of≤5-year-old hospitalized children diagnosed with HRSV through laboratory testing in two hospitals in Zhejiang Province from January 1 to May 31,2023,and analyze the disease burden of different population characteristics and risk factors for pneumonia.Results A total of 269 hospitalized cases of HRSV infection were included in this study,with pneumonia cases accounted for 232(86.25％).The median hospitalization cost for all cases was 4 326.21[interquartile range(IQR):3 281.74-5 599.92]yuan,and the median length of hospital stay was 6(IQR:4-7)d.The 0-＜1 year group had higher hospitalization costs(5 429.46 yuan vs.4 056.96 yuan)and longer hospital stays(6 d vs.5 d)compared to other age groups,with statistical significance(t=4.852,P＜0.01;t=2.618,P=0.010).Pneumonia cases had higher costs(4 212.49 yuan vs.4 052.31 yuan)and longer hospital stays(6 d vs.5 d)compared to non-pneumonia cases,with statistical significance(t=3.704,P=0.031;t=2.940,P=0.040),and mixed infections had higher costs(4 806.89 yuan vs.4 051.92 yuan)and longer hospital stays(6 d vs.5 d)compared to single infections),with statistical significance(t=3.538,P＜0.001;t=4.270,P＜0.01).Cesarean section(OR=12.72,95％CI:5.08-31.90),low birth weight(t=-3.074,P=0.002),and delayed hospital admission(t=4.880,P＜0.01)were risk factors for pneumonia in HRSV-infected hospitalized children.Conclusions Children under one-year-old with HRSV infection in the southern region of Zhejiang Province in 2023 have a heavy disease burden,and mixed infections,cesarean section,low birth weight,and delayed admission were identified as risk factors for increasing the burden of HRSV.
Human respiratory syncytial virusPneumoniaMixed infectionDisease burdenHospitalizationChildren
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NSTL
万方数据
