2023年浙江省南部地区住院儿童人呼吸道合胞病毒感染疾病负担研究
Study on the disease burden of hospitalized children with human respiratory syncytial virus infection in southern Zhejiang Province in 2023
孙琬琬 1潘金仁 1倪朝荣 2应丽红 3王璐敏 3叶夏良 4卢愉中 4朱安 5刘社兰1
作者信息
- 1. 浙江省疾病预防控制中心,浙江杭州 310051
- 2. 温州市疾病预防控制中心
- 3. 缙云县疾病预防控制中心
- 4. 丽水市疾病预防控制中心
- 5. 缙云县第二人民医院
- 折叠
摘要
目的 了解浙江省南部地区2023年≤5岁儿童人呼吸道合胞病毒(human respiratory syncytial virus,HRSV)感染住院病例的疾病负担.方法 收集2023年1月1日-5月31日,浙江省两家医院实验室检测确诊为HRSV的≤5岁住院儿童的诊疗资料,分析疾病负担以及发生肺炎的影响因素.结果 本次研究共纳入HRSV感染住院病例269例.肺炎病例232例(86.25％).全部病例的住院费用中位数为4 326.21(IQR:3 281.74～5 599.92)元;住院天数中位数为6(IQR:4～7)d.0～＜1岁儿童病例住院费用(5 429.46元vs.4 056.96元)和住院天数(6dvs.5d)高于其他年龄组,差异有统计学意义(t=4.852,P＜0.01;t=2.618,P=0.010);肺炎组住院费用(4 212.49元vs.4 052.31 元)和住院天数(6dvs.5d)高于非肺炎组,差异有统计学意义(t=3.704,P=0.031;t=2.940,P=0.040);混合感染住院费用(4 806.89元vs.4 051.92元)和住院天数(6dvs.5d)高于单一感染,差异有统计学意义(t=3.538,P＜0.01;t=4.270,P＜0.01).剖宫产(OR=12.72,95％CI:5.08～31.90)、低出生体质量(t=-3.074,P=0.002)和入院延迟(t=4.880,P＜0.01)为HRSV感染住院儿童发生肺炎的危险因素.结论 2023年浙江省南部地区0～＜1岁HRSV感染患儿具有较重的疾病负担,混合感染、剖宫产、出生时低体质量以及入院延迟可引起肺炎疾病负担增加.
Abstract
Objective To understand the disease burden of hospitalized cases of human respiratory syncytial virus(HRSV)infection in children aged ≤5 years in the southern region of Zhejiang Province in 2023.Methods Collect diagnosis and treatment data of≤5-year-old hospitalized children diagnosed with HRSV through laboratory testing in two hospitals in Zhejiang Province from January 1 to May 31,2023,and analyze the disease burden of different population characteristics and risk factors for pneumonia.Results A total of 269 hospitalized cases of HRSV infection were included in this study,with pneumonia cases accounted for 232(86.25％).The median hospitalization cost for all cases was 4 326.21[interquartile range(IQR):3 281.74-5 599.92]yuan,and the median length of hospital stay was 6(IQR:4-7)d.The 0-＜1 year group had higher hospitalization costs(5 429.46 yuan vs.4 056.96 yuan)and longer hospital stays(6 d vs.5 d)compared to other age groups,with statistical significance(t=4.852,P＜0.01;t=2.618,P=0.010).Pneumonia cases had higher costs(4 212.49 yuan vs.4 052.31 yuan)and longer hospital stays(6 d vs.5 d)compared to non-pneumonia cases,with statistical significance(t=3.704,P=0.031;t=2.940,P=0.040),and mixed infections had higher costs(4 806.89 yuan vs.4 051.92 yuan)and longer hospital stays(6 d vs.5 d)compared to single infections),with statistical significance(t=3.538,P＜0.001;t=4.270,P＜0.01).Cesarean section(OR=12.72,95％CI:5.08-31.90),low birth weight(t=-3.074,P=0.002),and delayed hospital admission(t=4.880,P＜0.01)were risk factors for pneumonia in HRSV-infected hospitalized children.Conclusions Children under one-year-old with HRSV infection in the southern region of Zhejiang Province in 2023 have a heavy disease burden,and mixed infections,cesarean section,low birth weight,and delayed admission were identified as risk factors for increasing the burden of HRSV.
关键词
人呼吸道合胞病毒/肺炎/混合感染/疾病负担/住院/儿童Key words
Human respiratory syncytial virus/Pneumonia/Mixed infection/Disease burden/Hospitalization/Children引用本文复制引用
出版年
2024
NETL
NSTL
万方数据