A prospective cohort study on the association between blood lipid levels and the risk of non-alcoholic fatty liver disease in a community population
Objective To assess the relationship between the blood lipid levels of community inhabitants and the risk of developing non-alcoholic fatty liver disease(NAFLD),to provide a basis for the comprehensive prevention and con-trol of NAFLD in community residents.Methods We conducted a prospective cohort study using the Shanghai Natural Population Songjiang sub-cohort.Key parameters measured included baseline triglyceride(TG),total choles-terol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)levels.We used proportional Cox and restricted cubic spline models to analyze the relationship between blood lipid levels and the risk of NAFLD,including a dose-response analysis.Results A total of 7 088 cohort participants were included in the study.Over a median follow-up of 2.96 years,NAFLD was newly diagnosed in 1 512 participants.The cumu-lative incidence rate was 21.33％(95％CI:20.38％-22.29％),with an annual average incidence rate of 7.21％and an incidence density of 78.80 per 1 000 person-years.Notably,higher baseline levels of TG,TC,LDL-C,and lower levels of HDL-C were observed in the NAFLD group compared to those without NAFLD,with statistically signifi-cant differences(P＜0.05).Multivariable Cox regression analysis revealed a positive correlation between baseline TG levels and NAFLD risk.The highest quintile group for TG levels had a 2.70 times higher risk of developing NAFLD compared to the lowest quintile group(95％CI:2.13-3.42).Conversely,higher baseline HDL-C levels were nega-tively correlated with NAFLD risk;the highest quintile group for HDL-C had a hazard ratio(HR)of 0.77(95％CI:0.62-0.96)compared to the lowest.The restricted cubic spline model indicated a non-linear relationship between blood lipid levels and NAFLD risk,including a"U"-shaped association for TC and LDL-C,a positive correlation for TG,and a negative correlation for HDL-C.Additionally,males had a higher risk of developing NAFLD compared to females.Conclusions The incidence of NAFLD among community residents in Shanghai is relatively high.Blood lipid levels may serve as independent risk factors for the development of NAFLD.
Non-alcoholic fatty liverBlood lipidsCohort studyRisk of morbidityCommunity
NETL
NSTL
万方数据
