Gender disparity in triglyceride glucose index and arteriosclerosis in hypertensive
Objective This study aimed to analyze the relationship between the triglyceride glucose(TyG)index and arteriosclerosis in patients with essential hypertension and to examine the gender difference.Methods Patients with essential hypertension were selected from the hypertension Center of Lanzhou University Second Hospital.Basic data were collected,including systolic blood pressure,diastolic blood pressure,heart rate,fasting blood glucose,and triglyceride levels.The difference in clinical data among different groups was compared.Logistic regression models were used to analyze the risk factors and gender differences in arteriosclerosis among patients with essential hypertension.In contrast,a multiple linear regression model was used to analyze the relationship between the TyG index and carotid-femoral artery pulse wave velocity(cf-PWV)in these patients.Results A total of 954 patients with essential hypertension were included in the analysis.As the TyG index increased,cf-PWV also increased gradually.The results of the multiple logistic regression model analysis showed that the risk of arteriosclerosis increased significantly with every 1-unit increase in the TyG index[OR=2.05,95％(confidence interval,CI):1.33-3.14,P=0.001).After gender stratification,the risk of atherosclerosis was higher in women(OR=1.41,95％CI:1.01-1.96,P=0.041),but not in men.The multiple linear regression analysis indicated that with each 1-unit increase in the TyG index,cf-PWV(β=0.12,95％CI:0.06-0.79,P=0.022).Compared to the reference group Q1,the increase in cf-PWV and TyG index was more significant in the whole population(β=0.33,95％CI:1.07-2.90,P＜0.01)and in women(β=0.53,95％CI:1.07-2.90,P＜0.01).Conclusions In patients with essential hypertension,the TyG index is significantly correlated with arteriosclerosis as assessed by cf-PWV,and this relationship is more pronounced in women.
NETL
NSTL
万方数据
