原发性高血压患者三酰甘油葡萄糖指数与高血压动脉硬化性别差异性研究
Gender disparity in triglyceride glucose index and arteriosclerosis in hypertensive
魏凌凤 1裴瑛 1张寅梅 1马婕 1张婧雯 1余静1
作者信息
- 1. 兰州大学第二医院心内科高血压中心,甘肃兰州 730000
- 折叠
摘要
目的 探讨原发性高血压患者三酰甘油葡萄糖(triglyceride glucose,TyG)指数与动脉硬化的关系及性别差异,为高危人群的干预提供依据.方法 选取就诊于兰州大学第二医院高血压中心的原发性高血压患者作为研究对象,收集患者基础资料,测定诊室收缩压、舒张压、心率、空腹血糖和三酰甘油等生化指标.比较不同组间研究对象临床资料的差异.采用logistic回归模型分析原发性高血压患者动脉硬化危险因素及性别差异,采用多元线性回归模型分析TyG指数与原发性高血压患者颈股动脉脉搏波传导速度(catroid-femoral artery pulse wave velocity,cf-PWV)的关系.结果 共纳入原发性高血压患者954例,随着TyG指数升高,cf-PWV也逐渐升高.多元logistic回归模型分析结果显示,TyG每增加1个单位,动脉硬化的风险显著增加[比值比(odds ratio,OR)=2.05,95％置信区间(confidence interval,CI):1.33～3.14,P=0.001],性别分层后,女性发生动脉硬化的风险更高(OR=1.41,95％CI:1.01～1.96,P=0.041).多元线性回归分析,TyG指数每增加1个单位,cf-PWV增加(β=0.12,95％CI:0.06～0.79,P=0.022).以 Q1 组为参照,全体人群(β=0.33,95％CI:1.07～2.90,P＜0.01)及女性(β=0.53,95％CI:1.07～2.90,P＜0.01)cf-PWV与TyG指数的升高更显著.结论 在原发性高血压中,TyG指数与cf-PWV评估的动脉硬化度显著相关,并且在女性中TyG指数与动脉硬化关系更密切.
Abstract
Objective This study aimed to analyze the relationship between the triglyceride glucose(TyG)index and arteriosclerosis in patients with essential hypertension and to examine the gender difference.Methods Patients with essential hypertension were selected from the hypertension Center of Lanzhou University Second Hospital.Basic data were collected,including systolic blood pressure,diastolic blood pressure,heart rate,fasting blood glucose,and triglyceride levels.The difference in clinical data among different groups was compared.Logistic regression models were used to analyze the risk factors and gender differences in arteriosclerosis among patients with essential hypertension.In contrast,a multiple linear regression model was used to analyze the relationship between the TyG index and carotid-femoral artery pulse wave velocity(cf-PWV)in these patients.Results A total of 954 patients with essential hypertension were included in the analysis.As the TyG index increased,cf-PWV also increased gradually.The results of the multiple logistic regression model analysis showed that the risk of arteriosclerosis increased significantly with every 1-unit increase in the TyG index[OR=2.05,95％(confidence interval,CI):1.33-3.14,P=0.001).After gender stratification,the risk of atherosclerosis was higher in women(OR=1.41,95％CI:1.01-1.96,P=0.041),but not in men.The multiple linear regression analysis indicated that with each 1-unit increase in the TyG index,cf-PWV(β=0.12,95％CI:0.06-0.79,P=0.022).Compared to the reference group Q1,the increase in cf-PWV and TyG index was more significant in the whole population(β=0.33,95％CI:1.07-2.90,P＜0.01)and in women(β=0.53,95％CI:1.07-2.90,P＜0.01).Conclusions In patients with essential hypertension,the TyG index is significantly correlated with arteriosclerosis as assessed by cf-PWV,and this relationship is more pronounced in women.
关键词
原发性高血压/三酰甘油葡萄糖指数/动脉硬化/颈股动脉脉搏波传导速度Key words
Essential hypertension/Triglyceride-glucose index/Arteriosclerosis/Carotid-femoral artery pulse wave velocity引用本文复制引用
基金项目
国家自然科学基金资助项目(81960086)
国家自然科学基金资助项目(82160089)
出版年
2024
NETL
NSTL
万方数据