Objective The incidence and death cases of stomach cancer(ICD-10 code:C16)in the cancer registration areas of Yunnan Province from 2012 to 2017 were collected and compiled.Methods The morbidity,mortality,standardized rate of stomach cancer,cumulative rate for 0-<75,and truncated rate for ages 35-<65 were calculated.A Joinpoint 4.8 was used to calculate the annual percentage change(APC).Results The results showed that the crude morbidity of stomach cancer in the cancer registration areas of Yunnan Province from 2012 to 2017 was 12.78/100 000,with a standardized rate of 8.70/100 000 and a world standardized rate of 8.62/100 000.The crude mortality rate of gastric cancer was 10.13/100 000,with a standardized rate of 6.72/100 000 and a world standardized rate of 6.64/100 000.Higher standardized morbidity and mortality rates were found in males than in females.The age-specific morbidity and mortality were at a low level at 0-<35 years of age,and rapidly increased after 35 years of age.The APC for morbidity and mortality was 3.70%(t=1.33,P=0.25)and 4.88%(t=1.80,P=0.15),respectively,and the APC for ASIR China and ASMR China were 1.48%(t=0.80,P=0.47)and 5.48%(t=1.25,P=0.28),respectively.There was no statistical difference in the trend of change.Conclusions The annual changes in the incidence and mortality of gastric cancer in Yunnan Province have no obvious increase or decrease,but the disease burden is still heavy.The prevention and treatment of gastric cancer should be guided by tertiary prevention strategies,and effective prevention measures should be taken according to local conditions.