The impact of early life famine on cardiovascular risk factors in the Zhuang ethnic minority residents in adulthood
Objective To investigate the effects of the severe early life famine on the clustering of cardiovascular disease risk factors among Zhuang ethnic minority residents.Methods A total of 1 957 urban and rural Zhuang ethnic minority residents aged 40 and above were taken as the study subjects.The study subjects were divided into the fetal experience group(n=176),childhood experience group(n=654),adolescent experience group(n=101),and non-exposure group(n=1 026)according to the date of birth.Differences in index levels and risk of metabolic abnormalities between groups were compared to analyze the aggregated relationship between early life famine exposure and cardiovascular risk factors.Results Logistic regression results showed that after adjusting for confounders,experiencing famine early in life was a risk factor for the development of hypertension,diabetes mellitus,dyslipidemia,and cardiovascular disease risk factor clustering;the risk of developing two cardiovascular risk factors from famine exposure during fetal life,childhood,and adolescence was 3.15 times(OR=3.15,95％CI:1.60-6.21),3.76 times(OR=3.76,95％CI:2.52-5.62),and 2.76 times(OR=2.76,95％CI:1.31-5.82)(P＜0.05).Conclusions Early life famine exposure increases the risk of cardiovascular disease risk factors in Zhuang ethnic minority residents in adulthood,and practicing reasonable interventions early in life can effectively prevent the occurrence of cardiovascular disease risk factors in adulthood.
NETL
NSTL
万方数据
