Prevalence and genotype distribution of human papilloma virus infection among 5 892 female patients in Guangzhou
Objective The current study aimed to investigate the prevalence and genotype distribution of human papilloma virus(HPV)among women in Guangdong province and to provide an epidemiological basis for the prevention and treatment of cervical cancer in this area.Methods Cervical exfoliated cell samples were collected from female outpatients and the health examination center of the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2021 to December 2021.HPV genotyping was performed using Polymerase Chain Reaction(PCR)-reverse dot blot hybridization.Results The overall HPV infection rate was 13.92％(820/5 892)in Guangzhou.Among the HPV-positive cases,637(77.68％)were infected with a single HPV genotype,140(17.07％)were infected with a dual HPV genotype and 43(5.25％)with multiple HPV genotypes.The infection rate of high-risk HPV(9.35％)was higher than that of low-risk HPV genotypes(3.00％)and mixed genotypes(1.56％).The top five most prevalent high-risk HPV genotypes were HPV52(3.60％),HPV58(1.49％),HPV16(1.46％),HPV53(1.17％),and HPV51(0.88％),while the top three most prevalent low-risk HPV genotypes were HPV44(1.17％),HPV54(0.70％)and HPV61(0.68％).The highest prevalence of HPV infection was found in women aged ≥60 years(29.34％),and significant differences were observed among different age groups(x2=47.44,P＜0.05).Conclusions The HPV infection rate among women in Guangzhou is relatively high.Efforts should be made to strengthen women's awareness of preventing HPV infection and to improve HPV screening and vaccination coverage.
Human papilloma virusPrevalenceGenotypingPCR-reverse dot blot hybridization
NETL
NSTL
万方数据
