目的 分析宁波市两家定点医院丙型肝炎病毒(hepatitis C virus,HCV)慢性感染者病毒基因型和感染途径分布,为丙型肝炎的防治提供依据.方法 纳入2011年4月-2021年12月在宁波市第二医院及宁波市第四医院确诊为慢性HCV感染者且基因型明确,分析不同检测时间、年龄和感染途径人群HCV基因型分布.结果 调查HCV感染者1 342例,基于定点医院就诊者的数据,HCV基因型检出数量(比例)呈逐年增长趋势,2020年达高峰192例(14.31％),2021年降至135例(10.06％).HCV感染前3位的基因型分别为1型659例(49.11％)、6型268例(19.97％)和3型208例(15.50％).每年仍以HCV基因型1型为主,但2015年之后3型和6型的所占比例总体呈增加趋势,后期组中3型及6型的构成比(18.07％和27.10％)均高于前期组(11.87％和9.89％),差异有统计学意义(x2=9.544、60.329,P＜0.01).男性感染HCV6型的构成比高于女性,差异有统计学意义(22.21％vs.17.27％,x2=5.072,P=0.024).以中青年(＞20～60岁)为主,1179例(87.85％);各年龄段间1型、2型、3型及6型的构成比差异有统计学意义(x2=112.986,P＜0.01);1型在＞50～60岁组的占比(64.42％)最高,2型在＞60岁组的占比(16.13％)最高,3型、6型在＞30～40岁年龄段中的占比(26.01％和26.59％)最高.能明确感染途径的患者345例,前3位为静脉药瘾86例、有偿献血史61例和不安全的针刺、注射、口腔诊疗57例;不同感染途径患者的年龄及性别总体比较差异有统计学意义(F=16.761,P＜0.01;x2=38.278,P＜0.01).结论 宁波市两定点医院就诊者HCV基因型分布呈多样性;1型、6型和3型为前3位基因型,不同基因型感染者的年龄、性别和感染途径等存在差异.
Infection route of different genotypes in hepatitis C virus infections from designated hospitals in Ningbo City
Objective To analyze the distributions and clinical characteristics of hepatitis C virus(HCV)geno-types in chronic HCV infections from two designated hospitals in Ningbo City,to provide evidence for heptitis C prevention and control.Methods Chronic HCV infections with confirmed HCV genotypes were enrolled in Ningbo No.2 Hospital and Ningbo Fourth Hospital in the period from April 2011 to December 2021.The distri-bution of HCV genotypes in patients detected at different time,age,and with infection route were analyzed.Results A total of 1 342 patients were included.Based on the data about chronic HCV infections visiting the designated hospitals,the number(and proportion)of HCV genotypes detected increased year by year,peaking at 192 cases(14.31％)in 2020,and decreasing to 135 cases(10.06％)in 2021.The top three genotypes in terms of frequency were genotype 1(659 cases,49.11％),genotype 6(268 cases,19.97％),and genotype 3(208 cases,15.50％).Genotype 1 predominated every year,however,after 2015,the proportion of genotype 3 and geno-type 6 showed an overall increasing trend.The proportions of genotype 3 and genotype 6 in the latter period(2017-2021,18.07％and 27.10％respectively)were higher than those in the earlier period(April 2011-2016,11.87％and 9.89％respectively)(x2=9.544,60.329,P＜0.01)..The proportion of genotype 6 in males was higher than that in females(22.21％vs.17.27％,x2=5.072,P=0.024).The patients were mainly young and middle-aged(＞20-60 years old)(1 179 cases,87.85％).There was statistically significant difference in the overall distribution of genotypes 1,2,3,and 6 across different age groups(x2=112.986,P＜0.01).The propor-tions of genotypes 1,2,3 and 6 were the highest in the＞50-60 years age group(64.42％),the＞60 years age group(16.13％),the＞30-40 years age group(26.01％),and the＞30-40 years age group(26.59％),respec-tively.There were 345 cases with confirmed infection route,with the top three routes being intravenous drug ad-diction(86 cases),history of paid blood donation(61 cases),and unsafe acupuncture,injection,and oral treat-ment(57 cases).There were statistically significant differences in age and gender of patients across different infec-tion routes(F=16.761,P＜0.01;x2=38.278,P＜0.01).Conclusions The distribution of HCV genotypes in the designated hospitals in Ningbo City is diverse,with genotypes 1,6 and 3 being the top three genotypes.There are differences in age,gender,and infection routes among HCV infections with different genotypes.
Hepatitis C virusHepatitis CGenotypeInfection route
万方数据
维普
