Objective This study aimed to understand the prevalence of infant food allergy,analyze its correlation with allergic diseases in first-degree relatives,and provide a scientific basis for the prevention and intervention of infant allergic diseases.Methods Eleven cities in the eastern,central,southern,and southwestern regions of China were selected as the research sites.In-patient pregnant women and their live-born infants from local maternal and child healthcare institutions from October 2018 to November 2019 were selected as the study subject.A baseline questionnaire survey was conducted for in-patient pregnant women,and four follow-up visits were carried out at 42 days postpartum and when the infants reached 3,6,and 12 months of age.The diagnosis of infant food allergy was based on clinical uniform criteria.The demographic characteristics of first-degree relatives of infants(mother,father,siblings)and the prevalence of allergic diseases(atopic dermatitis,food allergies,allergic rhinitis,and asthma)were collected using face-to-face interviews.Univariate and logistic multivariate models were used to analyze the correlation between infants and first-degree relatives with allergic diseases.Results The prevalence of food allergy among 2 681 infants was 6.12％.Infants with a family history of first-degree relative allergies had a prevalence of food allergy of 7.32％,with a prevalence of 11.24％in infants whose mothers and siblings had a history of allergy,while the prevalence was 5.19％in infants without a family history of allergy.Food allergy in mothers was significantly associated with food allergy in infants[(odds ratio,OR)=2.03,95％(confidence interval,CI):1.04-3.97).Allergic diseases in both mothers and siblings significantly increased the risk of food allergy(OR=2.44,95％CI:1.19-5.03).Conclusions The prevalence of allergic diseases is high in infancy,especially in those with a family history of allergies,particularly when the mother or siblings have a history of allergic diseases.
维普
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