Objective To analyze the clinical characteristics of Salmonella Typhimurium enteritis and its drug resistance in children,so as to provide evidence for the diagnosis and drug-resistance analysis of Salmonella Typhimurium enteritis in children.Methods Children diagnosed with Salmonella Typhimurium enteritis based on fecal culture in Xi'an Children's Hospital from 2018-2022 were retrospectively analyzed to summarize their clinical characteristics as well as drug resistance.Results A total of 82 patients were enrolled,including 47 boys and 35 girls,with a median age of 1.8 years and an interquartile range(IQR)of 1.1-2.8 years.The peak of incidence was observed in June to September each year.The affected children mainly had bloody purulent stools,watery stools and mucus stools,76 cases had fever,and 51 cases were co-morbid with respiratory tract infections.All the children were treated with antibiotics.The drug sensitivity test indicated that they were sensitive to imipenem,meropenem,ertapenem and piperacillin sodium and tazobactam sodium,and had high resistance rate to ampicillin(90.12％)and ampicillin sodium and sulbactam sodium(76.55％).Each strain showed different drug-resistance spectrum.Conclusions Children under 2 years are at high risk of Salmonella Typhimurium enteritis infection.The course of the disease is long and commonly to be prolonged,and the bacterial strains show multi-drug resistance,clinicians should choose appropriate antibiotics based on the results of drug sensitivity test in order to control the infection effectively.
万方数据
维普
