Objective To analyze the level and changing trends of mortality from major cardiovascular diseases in China from 2010 to 2020 and provide a reference for addressing cardiovascular disease control measures.Methods The mortality data of cerebrovascular disease,ischemic heart disease,and hypertensive heart disease were selected from the"China Death Cause Monitoring Dataset".The crude and age-standardized mortality rates of major cardiovascular diseases were calculated for different years,urban and rural areas,genders,and regions.The Joinpoint regression analysis was used to analyze the trends in age-standardized mortality rates.Results From 2010 to 2020,the crude mortality rate of cardiovascular disease increased from 238.12/100 000 to 328.84/100 000,while the age-standardized mortality rate dropped from 292.36/100 000 to 229.41/100 000,showing a downward trend(AAPC=-2.30%,P<0.01).Among them,the age-standardized mortality rates of cerebrovascular disease(AAPC=-3.80%,P<0.01)and ischemic heart disease(AAPC=-0.90%,P=0.20)both exhibited a downward trend,while that of hypertensive heart disease showed a relatively stable upward trend(AAPC=2.10%,P=0.20).The mortality rate of cardiovascular diseases increased with age.The age-standardized mortality rate of males was higher than that of females,and both displayed a downward trend,and the male decline rate was faster than that of females(AAPC male=-4.00%,AAPC female=-3.80%,P<0.05).The rural area was higher than the urban area,and both exhibited a downward trend,and the rural decline rate was faster than that of the urban area(AAPCrural area=-2.42%,AAPCurban area=-1.31%,P<0.05).Conclusions From 2010 to 2020,there were disparities in the mortality rates of major cardiovascular diseases in China based on urban-rural status,gender,and region.Targeted health promotion and management strategies should be provided to cope with the burden of cardiovascular diseases.