2014-2022年贵阳市围生儿神经管缺陷流行病学特征分析
Epidemiological characteristics analysis of neural tube defects during the perinatal infants in Guiyang City,from 2014 to 2022
龙琦 1唐恺 2杨佳熙 3王艳 3冯先美 1王云 3李佑龙 3顾怀云 3彭洁3
作者信息
- 1. 贵阳市妇幼保健院,贵州贵阳 550003;贵阳市妇幼保健计划生育服务中心
- 2. 贵州医科大学附属医院
- 3. 贵阳市妇幼保健院,贵州贵阳 550003
- 折叠
摘要
目的 分析贵州省贵阳市围生儿神经管缺陷(neural tube defects,NTDs)流行现状,为NTDs综合防控措施提供依据.方法 基于医院监测数据,将2014-2022年贵阳市80家出生缺陷医院监测机构内分娩的围生儿和监测到的NTDs缺陷儿纳入研究进行分析.采用x2检验比较不同特征围生儿NTDs发病率的差异,采用Joinpoint 4.9.1.0软件分析NTDs发病率的变化趋势.结果 2014-2022年贵阳市共监测到围生儿574 542例和NTDs 439例,其中≥28周胎龄检出 NTDs 120例,NTDs发病率为2.09/万.NTDs同时合并有其他先天性异常105例,合并最多的是马蹄内翻足19例.贵阳市围生儿NTDs发病率由2014年的6.77/万下降至2022年0.31/万,降幅达95.42％,围生儿NTDs发病率呈下降趋势.产妇不同年龄段、居住地和胎数NTDs发病率的差异有统计学意义(x2=38.035、74.582、16.561,P＜0.01).结论 2014-2022年贵阳市围生儿NTDs发病率呈下降趋势,孕妇居住在乡村、低龄(＜20岁)和多胎会增加孕期发生NTDs的风险.
Abstract
Objective This study aims to investigate the prevalence status of neural tube defects(NTDs)in Guiyang City,from 2014 to 2022 and to provide a basis for comprehensive prevention and control measures of NTDs.Methods Based on hospital monitoring data,this study analyzed perinatal infants and detected NTDs cases from 80 birth defect monitoring institutions in Guiyang City from 2014 to 2022.The Chi-square test was used to compare the difference in the incidence rates of NTDs among different groups,and the changing trend was analyzed using the Joinpoint 4.9.1.0 software.Results A total of 574 542 perinatal infants and 439 NTDs infants were monitored in Guiyang City from 2014 to 2022,including 120 cases of NTDs with a gestational age ≥ 28 weeks,resulting in a perinatal NTDs incidence rate of 2.09 per 10 000.105 NTDs cases were associated with different types of congenital anomalies,with the most common being talipes equinovarus 19 cases.The incidence rate of perinatal NTDs in Guiyang City decreased from 6.77/10 000 in 2014 to 0.31/10 000 in 2022,with a decrease of 95.42％.From 2014 to 2022,the overall incidence of the NTDs showed a decreasing trend.There were significant differences in the incidence of NTDs among different maternal ages,residential areas,and number of fetuses(x2=38.035,74.582,16.561,P＜0.01).Conclusions From 2014 to 2022,the incidence rates of NTDs in Guiyang City showed a downward trend.Pregnant women living in rural areas,with maternal age＜20,and with multiple fetuses are at increased risk of NTDs during pregnancy.
关键词
神经管缺陷/围生儿/发病率/流行病学特征Key words
Neural tube defects/Perinatal infants/Incidence/Epidemiological characteristics引用本文复制引用
出版年
2024
NETL
NSTL
万方数据