The patient,a male,presented on March 7,2023,with a self-palpable abdominal mass for 1 month and decreased appetite for 3 months.Based on comprehensive medical history,physical examination,laboratory and imaging results,he was diagnosed with retroperitoneal dedifferentiated liposarcoma.Because the patient has undergone 2 laparotomies within the past three months.Perioperative nutritional management is crucial.Considering the nutritional assessment,the patient's nutritional management is divided into three stages:(1)preoperative nutrition:oral nutritional supplements and partial parenteral nutrition to correct electrolyte imbalances and hypoproteinemia,aiming to improve the patient's surgical tolerance;(2)nil peros postoperative:phase total parenteral nutrition is used to focus on electrolytes,nutritional indicators,and intestinal function,with an early initiation of enteral nutrition;(3)postoperative phase with concurrent intestinal fistula:a sequential nutritional support plan is adopted,selecting appropriate enteral nutrition products and gradually increasing the intake of enteral nutrition.After 70 days of treatment and care,the patient fully recovered oral intake and was discharged on May 17.Retroperitoneal dedifferentiated liposarcoma is a rare malignant tumor that occurs in the retroperitoneal region,often with a large tumor size and numerous postoperative complications.Patient nutritional management is closely related to postoperative outcomes.