Objective To evaluate the surgical approach and efficacy of using bilateral transradial access for endovascular intervention in patients with severe stenosis or occlusion of the subclavian artery.Methods This study was a retrospective study.Clinical data of 20 patients with severe stenosis or occlusion of the subclavian artery who underwent interventional treatment via bilateral radial artery access in the Department of Neurology at Xi'an Gaoxin Hospital from January 2020 to April 2023 were collected.The differences in systolic blood pressure between the healthy side and the affected side before and after surgery were compared,along with the degree of subclavian artery stenosis.Normally distributed continuous variables are expressed as (xˉ)±s and analyzed using t-test.Non-normally distributed variables are expressed as M(Q1,Q3)and analyzed using non-parametric tests.Count data are expressed as cases(%)and analyzed using the χ2 test.Results All 20 patients with severe stenosis or occlusion of the subclavian artery underwent successful endovascular intervention via bilateral transradial access,achieving revascularization of the affected subclavian artery.The average difference in systolic blood pressure between the healthy side and the affected side decreased from(31.4±9.1)mmHg to 4.0(1.0,9.5)mmHg,and the degree of vascular stenosis decreased from(89.0±6.7)%to 6.5%(0,10.0%),with statistically significant differences(Z=-3.922,-3.929,all P<0.05).Clinical symptoms such as posterior circulation ischemia and ischemia of the affected upper limb improved after surgery,and no serious complications such as arterial dissection or embolism occurred.Conclusion Interventional treatment of severe stenosis or occlusion of the subclavian artery via bilateral transradial access is safe and effective.It can reduce patient bed rest time,improve patient comfort,and has certain clinical value for promotion.