中国医疗器械杂志2024,Vol.48Issue(1) :57-64.DOI:10.3969/j.issn.1671-7104.230152

止血黏合剂研究进展及设计考量

Research Progress and Design Strategy of Hemostatic Adhesives

赵琛玉 王涵 韩倩倩
中国医疗器械杂志2024,Vol.48Issue(1) :57-64.DOI:10.3969/j.issn.1671-7104.230152

止血黏合剂研究进展及设计考量

Research Progress and Design Strategy of Hemostatic Adhesives

赵琛玉 1王涵 1韩倩倩1
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作者信息

  • 1. 中国食品药品检定研究院,北京市,102629
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摘要

近年来,黏合剂在伤口闭合、止血和组织工程的应用中发展迅速,其不仅适用于湿组织的黏附,还可以适应组织器官的蠕动和机械拉伸,因而有防脱落性能,这对于动脉和器官出血来说尤为重要.随着技术的进一步发展,现有黏合剂可以通过不同策略对其改性,并且探索新材料,为黏合剂赋予了新的性能和用途,如药物递送、温敏性、光敏性等.尽管如此,对于未来黏合剂的设计及实际临床应用有许多值得商榷的地方.该文综述了传统黏合剂及其在止血应用中的最新研究进展,并讨论了未来黏合剂的设计和发展思路.

Abstract

Adhesives have emerged as an effective method for wound closure,hemostasis and tissue engineering in recent years,which not only are suitable for the adhesion of wet tissues,but also can adapt to the peristalsis and mechanical stretching of tissues and organs,especially for arteries and organize bleeding.With the further development of technology,existing adhesives can be modified through different strategies,and new materials are explored,giving new properties and uses to adhesives,such as drug delivery,temperature sensitivity,light sensitivity and so on.Nevertheless,there are many questions about the design and practical clinical application of adhesives in the future.The recent research progress of traditional adhesives and their application in hemostasis is reviewed,and the design and development ideas of future adhesives are discussed in the study.

关键词

组织黏附/生物材料/仿生类黏合剂

Key words

tissue adhesive/biomaterial/bioadhesive

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基金项目

国家重点研发计划(2022YFC2401802)

出版年

2024
中国医疗器械杂志
上海市医疗器械检测所

中国医疗器械杂志

CSTPCD
影响因子:0.503
ISSN:1671-7104
参考文献量66
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