首页|肠道菌群在肿瘤免疫治疗耐药中的作用机制研究进展

肠道菌群在肿瘤免疫治疗耐药中的作用机制研究进展

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肠道菌群多样性和组成与肿瘤免疫治疗效果相关,但是肠道菌群影响肿瘤免疫治疗耐药的机制鲜少总结和归纳.该文不仅阐述了目前肿瘤免疫治疗耐药的临床现状,还概括分析了肠道菌群的组成和稳态与不同类型肿瘤免疫治疗耐药的相关性及调控机制,为肠道菌群改善肿瘤免疫治疗耐药的潜在靶点研究提供参考.
Research progress on mechanism of intestinal microbiota in tumor immunotherapy resistance
Previous studies have shown that the diversity and composition of intestinal microbiota are related to the effect of tumor immunotherapy,but the mechanism of intestinal microbiota affecting tumor immunotherapy resistance has rarely been sum-marized.This article not only expounds the current clinical sta-tus of tumor immunotherapy resistance,but also summarizes the correlation and regulatory mechanism between the composition and homeostasis of intestinal microbiota and drug resistance to different types of tumor immunotherapy,so as to provide a refer-ence for the study of potential targets for improving tumor immu-notherapy resistance based on intestinal microbiota.

gut microbiotatumor immunotherapydrug resist-anceclinical statusresearch progressregulatory strategies

李慧玲、李晓曦、冯英楠、胡欣、张兰、董宪喆

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首都医科大学宣武医院药学部,北京 100053

遵义医科大学药学院,贵州遵义 563000

肠道菌群 肿瘤免疫治疗 耐药性 临床现状 研究进展 调控策略

2025

中国药理学通报
中国药理学会

中国药理学通报

北大核心
影响因子:1.54
ISSN:1001-1978
年,卷(期):2025.41(1)