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去亚甲基小檗碱的药理作用研究进展

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去亚甲基小檗碱(demethyleneberberine,DMB)是小檗碱在体内的主要代谢产物之一,其具有广泛的药理特性.大量研究表明其具有改善感染、抗炎、抗纤维化、抑制癌细胞、调节血脂等多种生物活性,而且在神经退行性疾病治疗领域有巨大潜力.该文通过对DMB药理作用及其机制进行系统概述,以期为深入理解其药理作用及合理开发提供科学依据.
Advances in pharmacological effects of demethyleneberberine
Demethyleneberberine(DMB),one of the active me-tabolite of berberine,displays versatile pharmacological proper-ties.Numerous studies indicate diverse biological activities,such as actions against infection,inflammation,fibrosis,cancer cells,blood lipids,etc.It presents considerable potential in treating neurodegenerative diseases.This article provides a con-cise review of the pharmacological actions and mechanisms made in demethyleneberberine research to facilitate a deeper under-standing of its pharmacology and provide a scientific foundation for its prudent development.

demethyleneberberinepharmacological effectsanti-infectionanti-inflammationhepatoprotectionneuropro-tection

李靖琪、张琪、陈雨桐、仝永斌、鲁澄宇

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广东医科大学药学院,广东东莞 523808

去亚甲基小檗碱 药理作用 抗感染 抗炎 肝保护 神经保护

2025

中国药理学通报
中国药理学会

中国药理学通报

北大核心
影响因子:1.54
ISSN:1001-1978
年,卷(期):2025.41(1)