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化疗诱导的周围神经病变的发病机制及治疗进展

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化疗诱导的周围神经病变(chemotherapy-induced pe-ripheral neuropathy,CIPN)是指使用抗肿瘤药物导致外周神经功能紊乱而表现出来的一些症状与体征,与化疗药物呈剂量相关性。CIPN的发病机制尚未完全明确,且现有的治疗药物和治疗方法疗效有限,因此探究CIPN的发病机制、研发新的治疗药物和治疗方法,解决未被满足的临床需求具有重要科学价值和社会意义。该文将从分子和细胞层面阐述CIPN的发病机制,以及对CIPN的治疗进展进行综述,为临床治疗提供参考,为未来研究提供方向。
The pathogenesis and treatment progress of chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy(CIPN)refers to some symptoms and signs of peripheral nerve dysfunc-tion caused by using anti-tumor drugs,which is related to the dose of chemotherapy drugs.The pathogenesis of CIPN has not been fully defined,and the efficacy of existing therapeutic drugs and methods is limited.Therefore,it is of great scientific value and social significance to explore the pathogenesis of CIPN,de-velop new therapeutic drugs and methods,and solve the unmet clinical needs.This paper will elaborate on the pathogenesis of CIPN from the molecular and cellular levels,and review the treatment progress of CIPN,so as to provide reference for clinical treatment and direction for future research.

chemotherapy-induced peripheral neuropathype-ripheral neurotoxicitychemotherapy-induced diseasedrug-re-lated side effects and adverse reactionstraditional Chinese med-icine therapytraditional Chinese medicine fumigation and wash-ing therapy

陆新、曲琳卓、王勇、关宏锏、吴艳玲

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延边大学附属医院神经内科,吉林延吉 133002

延边大学药学院长白山天然药物研究教育部重点实验室,吉林延吉 133002

化疗诱导的周围神经病变 外周神经毒性 化疗诱导疾病 药物相关性副作用和不良反应 中医药疗法 中医药熏洗疗法

2025

中国药理学通报
中国药理学会

中国药理学通报

北大核心
影响因子:1.54
ISSN:1001-1978
年,卷(期):2025.41(1)