首页|Dietary flaxseed oil regulate lipid metabolism associated with modulation of gut microbiota in high-fat-diet fed mice

Dietary flaxseed oil regulate lipid metabolism associated with modulation of gut microbiota in high-fat-diet fed mice

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
Accumulating data suggest that consuming dietary flaxseed oil (FSO) was a potential strategy for treating diet-induced lipid metabolism disorder (LMD). Effects of FSO on high-fat-diet (HFD) induced LMD and gut microbiota were studied in C57/BL6J mice. Results showed that FSO remarkably suppressed body weight gain induced by HFD and also attenuated LMD by decreasing levels of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acid (NEFA) and fasting blood-glucose (FBG) in serum. FSO treatment modulated mRNA expression level of genes associated with glucose and lipid metabolism. It regulated gut microbiome at different taxonomic levels by increasing proportions of beneficial Alistipes, Anaeroplasma, Bifidobacterium and inhibiting the growth of insulin resistance or obesity-associated bacteria such as Adlercreutzia, Dorea and Sporosarcina, compared with HFD group. Spearman's correlation analysis suggested that modulation of gut microbiota by FSO were closely related with LMD parameters. These findings might help us to better understand FSO impact on human health.

flaxseed oillipid metabolismgut microbiotahigh-fat-diet

Chen Yang、Zhenxia Xu、Zhou Xin、Qianchun Deng、Wenchao Chen、Fenghong Huang

展开 >

Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Wuhan, China

This work was supported by the Central Public-in-terest Scientific Institution Basal Research Fund for Chinese Academy of AgricuEarmarked Fund for China Ag-riculture Research Systemand the Agri-cultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences

1610172019009CARS-14CAAS-ASTIP-2013-OCRI

2019

中国油料作物学报(英文)
中国农业科学院油料作物研究所

中国油料作物学报(英文)

ISSN：2096-2428
年,卷(期)：2019.4(4)
  • 48