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Ameliorative effect of walnut oil against cognitive impairment in alzheimers type dementia in rodent

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Ameliorative effect of walnut oil against cognitive impairment in alzheimers type dementia in rodent
Walnut oil(WO),known for abundant polyunsaturated fatty acids and an array of bioactive substances such as tocopherols,phytosterols,squalene,melatonin,and polyphenols,which is endowed with numerous health ad-vantages.The primary objective of this research was to ascertain the impact of WO on cognitive deficits in learning and memory impairment mice caused by scopolamine(SCOP).The Morris water maze and the step-down avoidance test were utilized to assess the memory and learning capabilities.WO notably counteracted the detrimental effects of SCOP on learning and memory in the Morris water maze,as indicated by a reduction in escape latency and swimming distance.Likewise,WO administration led to a notably reduced number of errors in training trial and an increased latency in testing trial when compared to the SCOP group in the step-down avoidance test.Moreover,WO activated the cholinergic system of the brain by upregulating choline acetyl-transferase activity and reducing acetylcholinesterase activity.These results suggest that WO has the potential to protect against memory decline in mice,offering a promising strategy for the prevention of memory-related disorders.

Walnut oilScopolamineMemoryMorris water mazeStep-down avoidance testCholinergic system

Congcong Ma、Li Zhang、Lei Wang、Qingde Huang、Qianchun Deng、Fenghong Huang、Jiqu Xu

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Department of Nutriology,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan 430062,PR China

Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan 430062,PR China

Academy of Nutrition and Health,Hubei Province Key Laboratory of Occupational Hazard,Identification and Control,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,PR China

Department of Neurology,Hubei Provincial Hospital of Integrated Chinese&Western Medicine,No.11,Lingjiaohu Road,Wuhan 430015,PR China

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Walnut oil Scopolamine Memory Morris water maze Step-down avoidance test Cholinergic system

2024

10.1016/j.ocsci.2024.09.003

中国油料作物学报(英文)
中国农业科学院油料作物研究所

中国油料作物学报(英文)

ISSN：2096-2428
年,卷(期)：2024.9(4)