Objective:To establish a method for determining related substances of Ulipristal Acetate Tablets .Methods: HPLC was adopted and the separation was performed on a C18 column with a mixture of 0.01 mol? L-1 potassium dihydrogen phosphate and aceto-nitrile (35∶65) as mobile phase.The flow rate was 1.0 mL? min-1 and the detection wavelength was set at 304 nm.Results: The main peak of Ulipristal Acetate Tablets was well separated from degradation impurities .The main degradation impurity N-demethylulip-ristal acetate was identified and assayed .Conclusion:The newly established method can be used for quality control of Ulipristal Acetate Tablets .
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NSTL
维普
万方数据
