摘要
目的：：观察帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍的临床疗效和药品不良反应。方法：伴有睡眠障碍的抑郁症患者150例随机分为对照组与观察组各75例。观察组给予帕罗西汀片20~40 mg·d-1联合奥氮平片10 mg·d-1治疗，对照组单纯给予帕罗西汀片20~40 mg·d-1治疗，疗程均为4周。观察两组患者睡眠潜伏期、总睡眠时间、早醒时间和觉醒次数等指标，比较两组疗效和汉密尔顿抑郁量表( HAMD)评分。结果：观察组患者的睡眠潜伏期、总睡眠时间、觉醒时间以及觉醒次数都明显优于对照组(P<0.05)。治疗后，两组HAMD评分均较治疗前明显降低(P<0.05)，且观察组患者HAMD评分低于对照组患者(P<0.05)。观察组总有效率为94.7%，明显高于对照组的72.0%(P<0.05)；观察组药品不良反应发生率也高于对照组(P<0.05)。结论：帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍起效快，能迅速有效改善患者睡眠障碍症状，临床疗效好。
Abstract
Objective:To observe the clinical efficacy and adverse reactions of paroxetine combined with olanzapine in the treat-ment of depression complicated with sleep disorders. Methods: Totally 150 cases of sleep disorder patients were selected, and then randomly divided into the control group and the observation group with 75 ones in each. The control group was given paroxetine treat-ment, the observation group was given paroxetine combined with olanzapine treatment, and the treatment course was four weeks. The sleep latency, total sleep time, wake-up time and the number of awakening in the two groups were recorded, and the HAMD scale score and treatment efficacy were compared. Results:Compared with those in the control group, the sleep latency, total sleep time, wake-up time and the number of awakening in the observation group were obviously improved (P<0. 05). The clinical cure rate, the HAMD scale score and the incidence of adverse reactions between the two groups all had significant differences (P<0. 05). Conclu-sion:Paroxetine combined with olanzapine in the treatment of depression with sleep disorders shows fast efficacy, which can improve the sleep disorder symptoms and reduce the incidence of adverse reactions significantly.
NETL
NSTL
维普
万方数据