Effect of Yinqiao powder combined with Maxing Shigan decoction on modified formula Th1/Th2 and Th17/Treg cytokine levels in child mycoplasma pneumoniae pneumonia with syndrome of wind-heat invading lung
Objective To explore the clinical efficacy and effect of Yinqiao powder combined with Maxing Shigan decoction modified formula on Th1/Th2 and Th17/Treg cytokines on mycoplasma pneumonia(MPP).Methods MMP wind heat invading lung children hospitalized in Changshu Hospital Affiliated to Nanjing Universityof Chinese Medicine from October 2021 to June 2023 were selected as the study subjects.According to the random number method,they were divided into TCM group(azithromycin dry suspension + Yinqiao powder combined with Maxing Shigan decoction modified formula)and control group(azithromycin dry suspension).Before and 7 d after treatment,the clinical outcomes,TCM syndrome points(fever,cough,sputum,and wheezing points),lung function[forced vital capacity(FVC),maximum expiratory volume at 1 second(FEV 1),peak expiratory flow rate(PEF)],Th1/Th2 cytokines(IFN-γ and IL-4),and Th17/Treg cytokines(IL-17 and IL-10)were compared.The occurrence of adverse reactions during the treatment process were observed and recorded.Results A total of 106 MMP patients were included in the study,including 53 patients in each group.Before treatment,there was no significant difference between TCM group and control group in TCM syndrome integration,lung function,serum Th1/Th2 cytokkines and serum Th17/Treg cytokines(P>0.05).After treatment,TCM was significantly better than the control group(P<0.05);fever,asthma,cough,sputum,serum INF-γ levels and serum IL-17 levels were significantly lower(P<0.05),while FVC,FEV 1,PEF,IL-4 and IL-10 levels were significantly higher(P<0.05).The incidence of adverse reactions in the TCM group was significantly lower than that in the control group(P<0.05).Conclusion Yinqiao powder combined with Maxing Shigan decoction modified formula can regulate Th1/Th2 and Th17/Treg cytokine levels,improve lung function,and increase efficacy and safety in children with MMP.
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维普
